Primary lymphoepithelioma-like carcinoma of the ureter

Daniela S. Allende, Mihir Desai, Donna E. Hansel

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Lymphoepithelioma-like carcinoma (LELC) is an uncommon tumor of the urinary tract. We present a case of LELC involving the ureter of a 71-year-old male patient with gross hematuria. On biopsy, the patient was diagnosed with invasive poorly differentiated carcinoma, with a final diagnosis of LELC on subsequent nephroureterectomy. On resection, the neoplasm was solitary and consisted of undifferentiated neoplastic cells demonstrating a syncytial growth pattern, vesicular nuclei, prominent nucleoli, and an admixed polyclonal lymphoid infiltrate. Immunohistochemistry showed that the tumor cells were positive for Cam5.2 and CK7; focally positive for cytokeratinAE1/3, EMA, CK20, and p63; and negative for CK903. Epstein-Barr virus in situ hybridization was negative. No disease progression was noted at 5-month follow-up. Only 6 previous cases of LELC involving the ureter have been reported in the literature. We document an additional example of this uncommon entity and present a comprehensive review of LELC involving the ureter.

Original languageEnglish (US)
Pages (from-to)209-214
Number of pages6
JournalAnnals of Diagnostic Pathology
Issue number3
StatePublished - Jun 2010
Externally publishedYes


  • Diagnosis
  • Immunohistochemistry
  • Lymphoepithelioma-like
  • Ureter
  • Urothelial carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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