Primary non-Hodgkin's lymphoma of the liver

Vanita Noronha, Nelofar Q. Shafi, J. Antonio Obando, Shivaani Kummar

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations


We review the literature on primary hepatic lymphoma (PHL). PHL is a rare malignancy, and constitutes about 0.016% of all cases of non-Hodgkin's lymphoma. It has been reported to occur with increased frequency in patients with chronic hepatitis C infection. Most patients with PHL present with abdominal pain, constitutional symptoms and have hepatomegaly on examination. Imaging studies reveal solitary, or less often, multiple masses in the liver. The predominant histology is B-cell lymphoma, most commonly diffuse large cell type. Most patients are treated with chemotherapy, with some physicians employing a multimodality approach incorporating surgery and radiotherapy with chemotherapy. The prognosis is variable, with good response to early aggressive combination chemotherapy.

Original languageEnglish (US)
Pages (from-to)199-207
Number of pages9
JournalCritical Reviews in Oncology/Hematology
Issue number3
StatePublished - Mar 2005
Externally publishedYes


  • Hepatic lymphoma
  • Liver tumors
  • Non-Hodgkin's lymphoma

ASJC Scopus subject areas

  • Hematology
  • Oncology


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