Abstract
Recently, it has been shown in several animal models that more than 90% of host hepatocytes can be replaced by a small number of transplanted donor cells in a process we term therapeutic liver repopulation. This phenomenon is analogous to repopulation of the hematopoietic system after bone marrow transplantation. Liver repopulation occurs when transplanted cells have a growth advantage in the setting of damage to recipient liver cells. Here we review the current knowledge of this process and discuss the hopeful implications for treatment of liver diseases.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 7-14 |
| Number of pages | 8 |
| Journal | Seminars in Liver Disease |
| Volume | 19 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1999 |
Keywords
- Gene therapy
- Hepatocyte transplantation
- Liver repopulation
- Liver stem cell
ASJC Scopus subject areas
- Hepatology