Progesterone Sensitivity as a Cause of Recurrent Anaphylaxis

William J. Meggs, Ora Hirsch Pescovitz, Dean Metcalfe, D. Lynn Loriaux, Gordon Cutler, Michael Kaliner

Research output: Contribution to journalArticlepeer-review

64 Scopus citations


ANAPHYLACTIC or anaphylactoid attacks usually occur in immediate response to a specific inciting agent or event. Patients with recurring anaphylaxis in whom there is no evidence of an external cause are classified as having recurrent idiopathic anaphylaxis.1,2 One such patient had weekly life-threatening anaphylactic episodes that were partly controlled with intensive medical therapy combined with tracheal fenestration; however, spontaneous remission of the attacks during lactation led to the suspicion of sensitivity to sex hormones. Three clinical observations confirmed this suspicion: provocative challenges with minute quantities of progesterone caused an anaphylactic event, inhibition of pituitary gonadotropin release by luteinizing hormone-releasing hormone.

Original languageEnglish (US)
Pages (from-to)1236-1238
Number of pages3
JournalNew England Journal of Medicine
Issue number19
StatePublished - Nov 8 1984
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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