TY - JOUR
T1 - Prognostic utility of vitamin D in acute coronary syndrome patients in coastal Norway
AU - Naesgaard, Patrycja A.
AU - Pönitz, Volker
AU - Aarsetoey, Hildegunn
AU - Brügger-Andersen, Trygve
AU - Grundt, Heidi
AU - Harris, William S.
AU - Staines, Harry
AU - Nilsen, Dennis W.T.
N1 - Publisher Copyright:
© 2015 Patrycja A. Naesgaard et al.
PY - 2015
Y1 - 2015
N2 - Background: An inverse relationship between cardiovascular risk and levels of vitamin D and omega-3 index may exist. Objectives: To evaluate the prognostic utility of serum 25-hydroxyvitamin D [25(OH)D] in 871 patients with suspected acute coronary syndrome (ACS) and to assess the seasonal correlation between 25(OH)D and the omega-3 index in 456 ACS patients from southwestern Norway. Results: In the univariate analysis the hazard ratio (HR) at 2-year follow-up for all-cause mortality in the highest as compared to the lowest quartile of 25(OH)D in the total population was 0.61 (95% confidence interval (CI), 0.37-1.00), P = 0.050. At 7-year follow-up, the corresponding HR for all-cause mortality was 0.66 (95% CI, 0.49-0.90), P = 0.008, and for females alone 0.51 (95% CI, 0.32-0.83), P = 0.006. Quartile survival did not differ in the multivariable analysis, whereas 25(OH)D < 40 nM (<16 ng/mL) was found to be independently related to mortality. Seasonal differences in 25(OH)D, but not for the omega-3 index, were noted, and the two biomarkers were positively correlated, especially during winter-spring; Pearson's correlation coefficient was 0.358, P < 0.001. Conclusion: Vitamin D levels are related to survival, especially in females, and correlate with the omega-3 index.
AB - Background: An inverse relationship between cardiovascular risk and levels of vitamin D and omega-3 index may exist. Objectives: To evaluate the prognostic utility of serum 25-hydroxyvitamin D [25(OH)D] in 871 patients with suspected acute coronary syndrome (ACS) and to assess the seasonal correlation between 25(OH)D and the omega-3 index in 456 ACS patients from southwestern Norway. Results: In the univariate analysis the hazard ratio (HR) at 2-year follow-up for all-cause mortality in the highest as compared to the lowest quartile of 25(OH)D in the total population was 0.61 (95% confidence interval (CI), 0.37-1.00), P = 0.050. At 7-year follow-up, the corresponding HR for all-cause mortality was 0.66 (95% CI, 0.49-0.90), P = 0.008, and for females alone 0.51 (95% CI, 0.32-0.83), P = 0.006. Quartile survival did not differ in the multivariable analysis, whereas 25(OH)D < 40 nM (<16 ng/mL) was found to be independently related to mortality. Seasonal differences in 25(OH)D, but not for the omega-3 index, were noted, and the two biomarkers were positively correlated, especially during winter-spring; Pearson's correlation coefficient was 0.358, P < 0.001. Conclusion: Vitamin D levels are related to survival, especially in females, and correlate with the omega-3 index.
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U2 - 10.1155/2015/283178
DO - 10.1155/2015/283178
M3 - Article
C2 - 25722531
AN - SCOPUS:84924050293
SN - 0278-0240
VL - 2015
JO - Disease Markers
JF - Disease Markers
M1 - 283178
ER -