Abstract
The initial development of cytomegalovirus (CMV) as a vaccine vector for HIV/simian immunodeficiency virus (SIV) was predicated on its potential to pre-position high-frequency, effector-differentiated, CD8+ T cells in tissues for immediate immune interception of nascent primary infection. This goal was achieved and also led to the unexpected discoveries that non-human primate (NHP) CMVs can be programmed to differentially elicit CD8+ T cell responses that recognize viral peptides via classical MHC-Ia, and/or MHC-II, and/or MHC-E, and that MHC-E-restricted CD8+ T cell responses can uniquely mediate stringent arrest and subsequent clearance of highly pathogenic SIV, an unprecedented type of vaccine-mediated protection. These discoveries delineate CMV vector-elicited MHC-E-restricted CD8+ T cells as a functionally distinct T cell response with the potential for superior efficacy against HIV-1, and possibly other infectious agents or cancers.
Original language | English (US) |
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Pages (from-to) | 287-304 |
Number of pages | 18 |
Journal | Trends in Immunology |
Volume | 44 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2023 |
Keywords
- HIV vaccine
- SIV replication arrest
- cytomegalovirus
- immune programming
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology