TY - JOUR
T1 - Prosthetic Valve Endocarditis Caused by Staphylococcus epidermidis
T2 - Development of Rifampin Resistance During Vancomycin and Rifampin Therapy
AU - Chamovitz, Bruce
AU - Bryant, Richard E.
AU - Gilbert, David N.
AU - Hartstein, Alan I.
PY - 1985/5/17
Y1 - 1985/5/17
N2 - Development of rifampin-resistant Staphylococcus epidermidis was documented in three patients receiving vancomycin and rifampin therapy for prosthetic valve endocarditis. The minimum inhibitory concentrations and minimum bactericidal concentrations of rifampin for the original three isolates were 0.4 μg/mL or less. Organisms cultured during relapse or prosthetic valve replacement had minimum inhibitory concentrations of rifampin that were 12.5, 50, and greater than 100 μg/mL, respectively. Surgical intervention was necessary in all patients. One died, and one required a second prosthetic valve placement. The patients were treated with vancomycin plus aminoglycoside following identification of rifampin resistance. These observations suggest that vancomycin and rifampin may not be adequate therapy for prosthetic valve endocarditis caused by S epidermidis.
AB - Development of rifampin-resistant Staphylococcus epidermidis was documented in three patients receiving vancomycin and rifampin therapy for prosthetic valve endocarditis. The minimum inhibitory concentrations and minimum bactericidal concentrations of rifampin for the original three isolates were 0.4 μg/mL or less. Organisms cultured during relapse or prosthetic valve replacement had minimum inhibitory concentrations of rifampin that were 12.5, 50, and greater than 100 μg/mL, respectively. Surgical intervention was necessary in all patients. One died, and one required a second prosthetic valve placement. The patients were treated with vancomycin plus aminoglycoside following identification of rifampin resistance. These observations suggest that vancomycin and rifampin may not be adequate therapy for prosthetic valve endocarditis caused by S epidermidis.
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U2 - 10.1001/jama.1985.03350430079030
DO - 10.1001/jama.1985.03350430079030
M3 - Article
C2 - 3989962
AN - SCOPUS:0021879025
SN - 0098-7484
VL - 253
SP - 2867
EP - 2868
JO - JAMA: The Journal of the American Medical Association
JF - JAMA: The Journal of the American Medical Association
IS - 19
ER -