Proteinuria as a surrogate marker for renal outcome: Are we there yet?

Rupali S. Avasare, Jai Radhakrishnan

Research output: Contribution to journalComment/debatepeer-review

8 Scopus citations


Observational studies in glomerular diseases suggest that proteinuria reduction translates to improved outcomes. Because of a dearth of high-quality studies supporting this association, proteinuria is not universally recognized as a surrogate end point. Barbour et al. report on the longitudinal measure of proteinuria that best predicts hard renal outcomes. Their finding that time-varying proteinuria is the most reliable proteinuria metric is a necessary step in establishing proteinuria as a surrogate end point.

Original languageEnglish (US)
Pages (from-to)1228-1230
Number of pages3
JournalKidney International
Issue number6
StatePublished - Dec 1 2015
Externally publishedYes

ASJC Scopus subject areas

  • Nephrology


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