Pruritic dermatitis in asthmatic basenji-greyhound dogs: A model for human atopic dermatitis

James M. Butler; James E. Peters; Carol A. Hirshman; Clifton R. White; Leonid B. Margolin; Jon M. Hanifin

doi:10.1016/S0190-9622(83)70004-6

Pruritic dermatitis in asthmatic basenji-greyhound dogs: A model for human atopic dermatitis

James M. Butler, James E. Peters, Carol A. Hirshman, Clifton R. White, Leonid B. Margolin, Jon M. Hanifin

Dermatology

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

A recurrent, nonseasonal pruritic dermatitis manifested as lichenified plaques and as inflammatory nodules and papules in each of fourteen basenji-greyhound (B-G) crossbreed dogs, all of which demonstrated both nonspecific and Ascaris-specific airway hyperreactivity, with changes in pulmonary mechanics of the same order as those seen in symptomatic human asthma. Other features analogous to human atopic disease included blunted cyclic adenosine monophosphate (cAMP) responsiveness to beta adrenergic agents and in vivo release of histamine and slow-reacting substance of anaphylaxis in response to antigen aerosol challenge. The dermatitis appears to be a manifestation of the atopic state in these dogs and may provide an animal model for the study of human atopic dermatitis.

Original language	English (US)
Pages (from-to)	33-38
Number of pages	6
Journal	Journal of the American Academy of Dermatology
Volume	8
Issue number	1
DOIs	https://doi.org/10.1016/S0190-9622(83)70004-6
State	Published - 1983

ASJC Scopus subject areas

Dermatology

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10.1016/S0190-9622(83)70004-6

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@article{cc422b211a6a46bf80e27b7476c7b990,

title = "Pruritic dermatitis in asthmatic basenji-greyhound dogs: A model for human atopic dermatitis",

abstract = "A recurrent, nonseasonal pruritic dermatitis manifested as lichenified plaques and as inflammatory nodules and papules in each of fourteen basenji-greyhound (B-G) crossbreed dogs, all of which demonstrated both nonspecific and Ascaris-specific airway hyperreactivity, with changes in pulmonary mechanics of the same order as those seen in symptomatic human asthma. Other features analogous to human atopic disease included blunted cyclic adenosine monophosphate (cAMP) responsiveness to beta adrenergic agents and in vivo release of histamine and slow-reacting substance of anaphylaxis in response to antigen aerosol challenge. The dermatitis appears to be a manifestation of the atopic state in these dogs and may provide an animal model for the study of human atopic dermatitis.",

author = "Butler, {James M.} and Peters, {James E.} and Hirshman, {Carol A.} and White, {Clifton R.} and Margolin, {Leonid B.} and Hanifin, {Jon M.}",

note = "Funding Information: From the Departments of Dermatology, Anesthesiology, and Animal Care, Oregon Health Sciences University. Supported by a Dermatology Foundation-Ortho Fellowship and by grants from the National Institutes of Health (HL-25831 and AI 155557-01) and the Medical Research Foundation of Oregon. Accepted for publication May 12, 1982. Reprint requests to: Dr. Jon M. Hanifin, Department of Dermatol-ogy, Oregon Health Sciences University, 3181 S.W. Sam Jackson Park Rd., Portland, OR 97201.",

year = "1983",

doi = "10.1016/S0190-9622(83)70004-6",

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T2 - A model for human atopic dermatitis

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AU - Peters, James E.

AU - Hirshman, Carol A.

AU - White, Clifton R.

AU - Margolin, Leonid B.

AU - Hanifin, Jon M.

N1 - Funding Information: From the Departments of Dermatology, Anesthesiology, and Animal Care, Oregon Health Sciences University. Supported by a Dermatology Foundation-Ortho Fellowship and by grants from the National Institutes of Health (HL-25831 and AI 155557-01) and the Medical Research Foundation of Oregon. Accepted for publication May 12, 1982. Reprint requests to: Dr. Jon M. Hanifin, Department of Dermatol-ogy, Oregon Health Sciences University, 3181 S.W. Sam Jackson Park Rd., Portland, OR 97201.

PY - 1983

Y1 - 1983

N2 - A recurrent, nonseasonal pruritic dermatitis manifested as lichenified plaques and as inflammatory nodules and papules in each of fourteen basenji-greyhound (B-G) crossbreed dogs, all of which demonstrated both nonspecific and Ascaris-specific airway hyperreactivity, with changes in pulmonary mechanics of the same order as those seen in symptomatic human asthma. Other features analogous to human atopic disease included blunted cyclic adenosine monophosphate (cAMP) responsiveness to beta adrenergic agents and in vivo release of histamine and slow-reacting substance of anaphylaxis in response to antigen aerosol challenge. The dermatitis appears to be a manifestation of the atopic state in these dogs and may provide an animal model for the study of human atopic dermatitis.

AB - A recurrent, nonseasonal pruritic dermatitis manifested as lichenified plaques and as inflammatory nodules and papules in each of fourteen basenji-greyhound (B-G) crossbreed dogs, all of which demonstrated both nonspecific and Ascaris-specific airway hyperreactivity, with changes in pulmonary mechanics of the same order as those seen in symptomatic human asthma. Other features analogous to human atopic disease included blunted cyclic adenosine monophosphate (cAMP) responsiveness to beta adrenergic agents and in vivo release of histamine and slow-reacting substance of anaphylaxis in response to antigen aerosol challenge. The dermatitis appears to be a manifestation of the atopic state in these dogs and may provide an animal model for the study of human atopic dermatitis.

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Pruritic dermatitis in asthmatic basenji-greyhound dogs: A model for human atopic dermatitis

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