@article{3fca4ce011904d7bba55e96ff72a37de,
title = "Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways",
abstract = "Genome-wide association studies (GWAS) of psychiatric disorders have identified multiple genetic associations with such disorders, but better methods are needed to derive the underlying biological mechanisms that these signals indicate. We sought to identify biological pathways in GWAS data from over 60,000 participants from the Psychiatric Genomics Consortium. We developed an analysis framework to rank pathways that requires only summary statistics. We combined this score across disorders to find common pathways across three adult psychiatric disorders: schizophrenia, major depression and bipolar disorder. Histone methylation processes showed the strongest association, and we also found statistically significant evidence for associations with multiple immune and neuronal signaling pathways and with the postsynaptic density. Our study indicates that risk variants for psychiatric disorders aggregate in particular biological pathways and that these pathways are frequently shared between disorders. Our results confirm known mechanisms and suggest several novel insights into the etiology of psychiatric disorders.",
author = "{The Network and Pathway Analysis Subgroup of the Psychiatric Genomics Consortium} and {International Inflammatory Bowel Disease Genetics Consortium (IIBDGC)} and Colm O{\textquoteright}dushlaine and Lizzy Rossin and Lee, {Phil H.} and Laramie Duncan and Parikshak, {Neelroop N.} and Stephen Newhouse and Stephan Ripke and Neale, {Benjamin M.} and Purcell, {Shaun M.} and Danielle Posthuma and Nurnberger, {John I.} and Lee, {S. Hong} and Faraone, {Stephen V.} and Perlis, {Roy H.} and Mowry, {Bryan J.} and Anita Thapar and Goddard, {Michael E.} and Witte, {John S.} and Devin Absher and Ingrid Agartz and Huda Akil and Farooq Amin and Andreassen, {Ole A.} and Adebayo Anjorin and Richard Anney and Verneri Anttila and Arking, {Dan E.} and Philip Asherson and Azevedo, {Maria H.} and Lena Backlund and Badner, {Judith A.} and Bailey, {Anthony J.} and Tobias Banaschewski and Barchas, {Jack D.} and Barnes, {Michael R.} and Barrett, {Thomas B.} and Nicholas Bass and Agatino Battaglia and Michael Bauer and M{\`o}nica Bay{\'e}s and Frank Bellivier and Bergen, {Sarah E.} and Wade Berrettini and Catalina Betancur and Thomas Bettecken and Joseph Biederman and Binder, {Elisabeth B.} and Black, {Donald W.} and Blackwood, {Douglas H.R.} and Eric Fombonne",
note = "Funding Information: G.B. and S.N. acknowledge funding support for this work from the National Institute for Health Research (NIHR) Mental Health Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King{\textquoteright}s College London. P.H.L. is supported by US National Institute of Mental Health (NIMH) grant K99MH101367. The PGC Cross-Disorder Group is supported by NIMH grant U01 MH085520. Statistical analyses were carried out on the Genetic Cluster Computer, which is financially supported by the Netherlands Scientific Organization (NOW; 480-05-003; principal investigator D.P.) along with a supplement from the Dutch Brain Foundation and VU University. Numerous (>100) grants from government agencies along with substantial private and foundation support worldwide enabled the collection of phenotype and genotype data, without which this research would not be possible. Publisher Copyright: {\textcopyright} 2015 Nature America, Inc. All rights reserved.",
year = "2015",
month = feb,
day = "17",
doi = "10.1038/nn.3922",
language = "English (US)",
volume = "18",
pages = "199--209",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "2",
}