Pulmonary function in heterozygotes for alpha1-antitrypsin deficiency: A case control study

A. S. Buist, G. J. Sexton, A. M.H. Azzam, B. E. Adams

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37 Scopus citations


In this paper we present the initial cross-sectional data from a prospective study of lung aging in heterozygotes for α1-antitrypsin deficiency. Using a case-control design, our cases included 37 heterozygotes for α1-antitrypsin deficiency, protease inhibitor phenotypes MZ and MS, selected because they were parents of children with homozygous α1-antitrypsin deficiency identified in a statewide newborn screening program between 1971 and 1974. All of the heterozygotes were less than 40 yr of age. Our control subjects were selected from a random sample of a working population participating in a longitudinal study of lung aging, using a 2:1 match of control subjects to cases, matching age, sex, ethnic origin, and smoking. Using a respiratory symptom questionnaire, spirometry, and the single-breath N2 test, we found no significant difference between heterozygotes and control subjects in terms of respiratory symptoms or pulmonary function data. We conclude that to 40 yr of age, the heterozygous phenotype (Pi MZ and MS) is not a risk factor for impairment of pulmonary function.

Original languageEnglish (US)
Pages (from-to)759-766
Number of pages8
JournalAmerican Review of Respiratory Disease
Issue number4
StatePublished - 1979

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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