Abstract
Adaptive Optics (AO) for scanning laser ophthalmoscopy enables high-resolution retinal imaging that can be used for preclinical research of diseases causing vision loss. Pupil Segmentation (PS) is an approach to wavefront-sensorless AO that acquires images within subregions across the imaging pupil to measure the wavefront slopes at the corresponding locations of the beam. We present PS-AO as an approach to correct ocular aberrations in 7 s, implemented to minimize respiratory motion from an anesthetized mouse. We demonstrated an improvement in resolution and an image intensity increase of 25% across all results using PS-AO for in vivo fluorescence retinal imaging in mice using a MEMS-based segmented deformable mirror.
Original language | English (US) |
---|---|
Pages (from-to) | 1365-1368 |
Number of pages | 4 |
Journal | Optics Letters |
Volume | 42 |
Issue number | 7 |
DOIs | |
State | Published - Apr 1 2017 |
Externally published | Yes |
ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics