Quantitative biliary dynamics: introduction of a new noninvasive scintigraphic technique

G. T. Krishnamurthy, V. R. Bobba, D. McConnell, F. Turner, M. Mesgarzadeh, E. Kingston

Research output: Contribution to journalArticlepeer-review

72 Scopus citations


We used a Tc-99m-labeled hepatobiliary agent to measure the partition of hepatic bile between gallbladder and intestine in sixteen normal patients and nine patients with cholelithiasis. In normal subjects, the fractions of the hepatic bile that flow into the gallbladder and the small intestine were widely variable, with mean values of 69 ± 7% (s.e.) and 31 ±7% respectively. Bile reflux into the common hepatic duct was rare, occurring during the first 2/3 of the gallblader ejection period and only when the ejection fraction was greater than 59%. The gallbladder's mean latent period, ejection period, ejection fraction, and ejection rate were 2 ± 1 min, 11 ± 1min, 59 ±4%, and 5.9%/min respectively. In patients with cholelithiasis, the fraction of hepatic bile flowing into the gallbladder was normal, but the ejection fraction was significantly reduced (p<0.005). For an equivalent dose of cholecystokinin, the gallbladder in cholelithiasis is less responsive than in normal subjects.

Original languageEnglish (US)
Pages (from-to)217-223
Number of pages7
JournalJournal of Nuclear Medicine
Issue number3
StatePublished - 1983

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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