TY - JOUR
T1 - Quantitative three-dimensional microscopy approaches with applications in breast cancer biology including measurement of genomic instability
AU - Lockett, Stephen
AU - Solorzano, Carlos Ortiz
AU - Baggett, Daniel
AU - Chin, Koei
N1 - Funding Information:
This project has been funded in part with federal funds from the National Cancer Institute,
PY - 2004/10
Y1 - 2004/10
N2 - Understanding tissue development, tissue homeostasis and what goes wrong in these processes during tumorigenesis, requires knowledge of the kinetics of multiple, molecular pathways in individual cells while cells are in their tissue context. This review outlines progress and future directions necessary in quantitative microscopy for gaining this knowledge, using the mammary gland as a model system.
AB - Understanding tissue development, tissue homeostasis and what goes wrong in these processes during tumorigenesis, requires knowledge of the kinetics of multiple, molecular pathways in individual cells while cells are in their tissue context. This review outlines progress and future directions necessary in quantitative microscopy for gaining this knowledge, using the mammary gland as a model system.
KW - Fluorescence microscopy
KW - Genomic instability
KW - Mammary gland
KW - Quantitative 3D imaging
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U2 - 10.1007/s10911-004-1408-6
DO - 10.1007/s10911-004-1408-6
M3 - Review article
C2 - 15838607
AN - SCOPUS:22944442665
SN - 1083-3021
VL - 9
SP - 383
EP - 391
JO - Journal of Mammary Gland Biology and Neoplasia
JF - Journal of Mammary Gland Biology and Neoplasia
IS - 4
ER -