Quantum dots monitor TrkA receptor dynamics in the interior of neural PC12 Cells

Sujata Sundara Rajan; Tania Q. Vu

doi:10.1021/nl0612650

Quantum dots monitor TrkA receptor dynamics in the interior of neural PC12 Cells

Sujata Sundara Rajan, Tania Q. Vu

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

Can quantum dots (QDs) serve as physiologically relevant receptor probes in the interior of cells? We directly visualize endocytosis, redistribution, and shuttling of QD bound-TrkA receptors to PC12 neural processes and far-reaching growth cone tips. Internalized QDs are contained in microtubule-associated vesicles and possess transport properties that reflect TrkA receptor dynamics. This opens up new possibilities for the development of QD platforms as molecular tools to image biochemical signaling and transport cargo in the cell interior.

Original language	English (US)
Pages (from-to)	2049-2059
Number of pages	11
Journal	Nano Letters
Volume	6
Issue number	9
DOIs	https://doi.org/10.1021/nl0612650
State	Published - Sep 2006

ASJC Scopus subject areas

Bioengineering
Chemistry(all)
Materials Science(all)
Condensed Matter Physics
Mechanical Engineering

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10.1021/nl0612650

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abstract = "Can quantum dots (QDs) serve as physiologically relevant receptor probes in the interior of cells? We directly visualize endocytosis, redistribution, and shuttling of QD bound-TrkA receptors to PC12 neural processes and far-reaching growth cone tips. Internalized QDs are contained in microtubule-associated vesicles and possess transport properties that reflect TrkA receptor dynamics. This opens up new possibilities for the development of QD platforms as molecular tools to image biochemical signaling and transport cargo in the cell interior.",

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Quantum dots monitor TrkA receptor dynamics in the interior of neural PC12 Cells

Abstract

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