Quisqualate receptor-mediated depression of calcium currents in hippocampal neurons

Robin A.J. Lester, Craig E. Jahr

Research output: Contribution to journalArticlepeer-review

159 Scopus citations


The modulation of Ca2+ currents by the excitatory neurotransmitter glutamate and its analogs was investigated in hippocampal neurons in culture. In the presence of glutamate receptor-gated ion channel antagonists, all of the analogs tested caused either a small reversible depression or had no effect on the Ca2+ current. However, in neurons dialyzed with GTPyS, quisqualate and glutamate but not NMDA, kainate, AMPA, or l-APB caused marked and irreversible depressions of the Ca2+ current. This inhibition was only observed if Ca2+ was present in either the internal or external medium. Intracellular H-7, staurosporine, IP3, cAMP, cGMP, or calmodulin inhibitors failed to prevent the quisqualate-induced Ca2+ current inhibition. These observations are consistent with an interaction between a G protein-coupled glutamate receptor and Ca2+ channels.

Original languageEnglish (US)
Pages (from-to)741-749
Number of pages9
Issue number5
StatePublished - May 1990

ASJC Scopus subject areas

  • Neuroscience(all)


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