Abstract
Variation in fibronectin (Fn) levels and white blood cell counts (WBC) following staphylococcal enterotoxin B (SEB) or SEB + cryoprecipitate containing Fn challenge was studied in New Zealand white rabbits. Increased plasma Fn levels were observed 2 h after the intravenous injection of SEB and peaked at 48-72 h (from a mean level 194.6 ± 4.5 µg/ml prechallenge Fn level to a 72-hour postchallenge mean level of 407.9 ± 25.4 µg/ml). Fn levels then decreased over the succeeding 5 days to approximately prechallenge levels. The total WBC count decreased by 88% within 2 h after the SEB injection. A slow increase in circulatory WBC was observed over the next 24 h. SEB caused an increase in plasma Fn levels and decreased WBC counts with lymphopenia that was followed by a normal lymphocyte count within 5 days. These data suggest that an acute-phase reaction was induced by interleukin-1. Fn prophylaxis provided no change in clinical signs when given at the time of SEB injection.
Original language | English (US) |
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Pages (from-to) | 191-194 |
Number of pages | 4 |
Journal | Gynecologic and Obstetric Investigation |
Volume | 28 |
Issue number | 4 |
DOIs | |
State | Published - 1989 |
Keywords
- Acute-phase reaction
- Enterotoxin B
- Fibronectin
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynecology