Racial differences in response to glaucoma medications in ocular hypertensive patients

G. R. Bennett, G. A. Cioffi, D. Dorr, M. Gordon, A. Beck, R. Fechtner, M. Kass

Research output: Contribution to journalArticlepeer-review


Purpose To compare the response to various intraocular pressure (IOP) lowering medications among different racial groups of ocular hype-tensive (OH) subjects Methods The Ocular Hypertension Treatment Study (OHTS) is a long-term, randomized, multicenter clinical trial to determine if reduction of IOP prevents or delays the onset of glaucoma in OH subjects. Over 1600 subjects (375 AfricanAmerican & 1229 Other Racial Group) were randomized to either IOP lowering therapy or monitoring Initial therapy was in one eye and the choice of IG? lowering agents was individual physician preference. Demographic features, systemic disease & IOP lowering were compared among the 2 groups. Results Afr-Amer Other Mean Age (yrs) 54 56 Age, educational level & other Male: Female % 34:66 46:54 demographics were similar, while Systemic Htn % 57 32 history of heart disease, systemic Diabetes % 18 9 hypertension, and diabetes mellitus IOP % Change were significantly more prevalent in the Treated Eye -24 -25 African-Amer. group. IOP lowering Untreated Eye -8 -6 was equivalent amoung groups. Conclusions Initial response to 1OP lowering medications appear equal between African-Americans and other racial groups.

Original languageEnglish (US)
Pages (from-to)S278
JournalInvestigative Ophthalmology and Visual Science
Issue number4
StatePublished - 1997
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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