Radiation-induced painful neurogenic hypertrophy treated with botulinum toxin A

Alexandra Filippakis, Doreen T. Ho, Juan E. Small, Kirstin M. Small, Erik R. Ensrud

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Painful neurogenic hypertrophy is a rare complication of radiation therapy. We report a 27-year-old woman with a history of adenoid cystic carcinoma of the submandibular gland presented with painful twitching of her left shoulder. Electrodiagnostic studies were consistent with a diagnosis of radiation-induced spinal accessory nerve hyperactivity. The patient failed conventional medical therapy. She was treated with an injection of botulinum toxin A, and within 1 month experienced significant relief of symptoms. We thus conclude that Botulinum toxin is a therapeutic option for the pain associated with radiation-induced peripheral nerve hyperactivity.

Original languageEnglish (US)
Pages (from-to)135-137
Number of pages3
JournalJournal of clinical neuromuscular disease
Issue number3
StatePublished - 2018


  • Botulinum toxin
  • Neurogenic hypertrophy
  • Radiation

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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