@article{2b6159dc9a18469ab737420f5358be77,
title = "Randomized trial to assess the impact of venlafaxine and soy protein on hot flashes and quality of life in men with prostate cancer",
abstract = "Purpose: Hot flashes occur in approximately 80% of androgen-deprived men. Few intervention studies have been conducted to relieve hot flashes in men. Patients and Methods: Eligible androgen-deprived men were randomly assigned to one of four daily regimens (2 × 2 factorial design) for 12 weeks: milk protein powder and placebo pill, venlafaxine and milk protein powder, soy protein powder and placebo pill, or venlafaxine and soy protein powder. The primary end point was hot flash symptom severity score (HFSSS), defined as number of hot flashes times severity. The secondary end point was quality of life (QoL), assessed by using the Functional Assessment of Cancer Therapy-Prostate. Results: In all, 120 men age 46 to 91 years participated. Most were white (78%) and overweight or obese (83%). Toxicity was minimal. Neither venlafaxine nor soy protein alone or in combination had a significant effect on HFSSS. Soy protein, but not venlafaxine, improved measures of QoL. Conclusion: In androgen-deprived men, neither venlafaxine nor soy proved effective in reducing hot flashes. Interventions that appear effective for decreasing hot flashes in women may not always turn out to be effective in men.",
author = "Vitolins, {Mara Z.} and Leah Griffin and Tomlinson, {W. Vic} and Jacqueline Vuky and Adams, {Paul T.} and Dawn Moose and Bart Frizzell and Lesser, {Glenn J.} and Michelle Naughton and Radford, {James E.} and Shaw, {Edward G.}",
note = "Funding Information: Supported by Grant No. U10 CA 081851 from the National Cancer Insti tute/Division of Cancer Prevention, Grant No. U10 CA 081851-06S2 from the National Center for Complementary and Alternative Medicine (NCCAM), and Physicians Pharmaceuticals. Funding for the purchase of the EffexorXR tablets and placebo pills was obtained through Grant No. U10 CA081851-06S2 from NCCAM. The soy and milk protein powders were provided free of charge by Physicians Pharmaceuticals. Funding Information: Supported by Grant No. U10 CA 081851 from the National Cancer Institute/Division of Cancer Prevention, Grant No. U10 CA 081851-06S2 from the National Center for Complementary and Alternative Medicine (NCCAM), and Physicians Pharmaceuticals. Funding for the purchase of the EffexorXR tablets and placebo pills was obtained through Grant No. U10 CA081851-06S2 from NCCAM. The soy and milk protein powders were provided free of charge by Physicians Pharmaceuticals. Publisher Copyright: {\textcopyright} 2013 by American Society of Clinical Oncology.",
year = "2013",
month = nov,
day = "10",
doi = "10.1200/JCO.2012.48.1432",
language = "English (US)",
volume = "31",
pages = "4092--4098",
journal = "Journal of Clinical Oncology",
issn = "0732-183X",
publisher = "American Society of Clinical Oncology",
number = "32",
}