Rapid and safe response to low-dose carbamazepine in neonatal epilepsy

Tristan T. Sands, Martina Balestri, Giulia Bellini, Sarah B. Mulkey, Olivier Danhaive, Eliza Hayes Bakken, Maurizio Taglialatela, Michael S. Oldham, Federico Vigevano, Gregory L. Holmes, Maria Roberta Cilio

Research output: Contribution to journalArticlepeer-review

87 Scopus citations


Objective: To evaluate treatment responses in benign familial neonatal epilepsy (BFNE). Methods: We recruited patients with BFNE through a multicenter international collaboration and reviewed electroclinical and genetic details, and treatment response. All patients were tested at minimum for mutations/deletions in the KCNQ2, KCNQ3, and SCN2A genes. Results: Nineteen patients were included in this study. A family history of neonatal seizures was positive in 16 patients, and one additional patient had a family history of infantile seizures. Mutations or deletions of KCNQ2 were found in 14, and of KCNQ3 in 2, of the 19 patients. In all patients, seizures began at 2–5 days of life and occurred multiple times per day. Four patients developed status epilepticus. Seizures were focal, alternating between hemispheres, and characterized by asymmetric tonic posturing associated with apnea and desaturation, followed by unilateral or bilateral asynchronous clonic jerking. Twelve of 19 patients were treated with multiple medications prior to seizure cessation. Seventeen of (88%) 19 patients were seizure-free within hours of receiving oral carbamazepine (CBZ) or oxcarbazepine (OXC). Earlier initiation of CBZ was associated with shorter hospitalization (p < 0.01). No side effects of CBZ were reported. All patients had normal development and remain seizure-free at a mean follow-up period of 7.8 years (6 months–16 years). Significance: This study provides evidence that CBZ is safe and rapidly effective in neonates with BFNE, even in status epilepticus. We propose that CBZ should be the drug of choice in benign familial neonatal seizures.

Original languageEnglish (US)
Pages (from-to)2019-2030
Number of pages12
Issue number12
StatePublished - Dec 1 2016
Externally publishedYes


  • Benign familial neonatal epilepsy
  • Carbamazepine
  • KCNQ2
  • KCNQ3
  • Neonatal seizures
  • Oxcarbazepine

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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