Rapid identification of improved protein ligands using peptoid microarrays

Hyun Suk Lim; M. Muralidhar Reddy; Xiangshu Xiao; Johnnie Wilson; Rosemary Wilson; Steven Connell; Thomas Kodadek

doi:10.1016/j.bmcl.2009.03.153

Rapid identification of improved protein ligands using peptoid microarrays

Hyun Suk Lim, M. Muralidhar Reddy, Xiangshu Xiao, Johnnie Wilson, Rosemary Wilson, Steven Connell, Thomas Kodadek

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

A rapid array-based protocol is presented by which a modest affinity protein-binding small molecule can be appended to a library of peptoids via click chemistry. The array can then be screened for improved ligands that exhibit a higher affinity for the protein target.

Original language	English (US)
Pages (from-to)	3866-3869
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	14
DOIs	https://doi.org/10.1016/j.bmcl.2009.03.153
State	Published - Jul 15 2009
Externally published	Yes

Keywords

Click chemistry
Combinatorial chemistry
Library screening
Microarray
Peptoid

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2009.03.153

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title = "Rapid identification of improved protein ligands using peptoid microarrays",

abstract = "A rapid array-based protocol is presented by which a modest affinity protein-binding small molecule can be appended to a library of peptoids via click chemistry. The array can then be screened for improved ligands that exhibit a higher affinity for the protein target.",

keywords = "Click chemistry, Combinatorial chemistry, Library screening, Microarray, Peptoid",

author = "Lim, {Hyun Suk} and {Muralidhar Reddy}, M. and Xiangshu Xiao and Johnnie Wilson and Rosemary Wilson and Steven Connell and Thomas Kodadek",

note = "Funding Information: This work was supported by a contract from the National Heart, Lung, and Blood Institute (NO1-HV-28185) for the UT Southwestern Center for Proteomics Research and a grant from the Welch Foundation (I-1299). ",

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doi = "10.1016/j.bmcl.2009.03.153",

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AU - Lim, Hyun Suk

AU - Muralidhar Reddy, M.

AU - Xiao, Xiangshu

AU - Wilson, Johnnie

AU - Wilson, Rosemary

AU - Connell, Steven

AU - Kodadek, Thomas

N1 - Funding Information: This work was supported by a contract from the National Heart, Lung, and Blood Institute (NO1-HV-28185) for the UT Southwestern Center for Proteomics Research and a grant from the Welch Foundation (I-1299).

PY - 2009/7/15

Y1 - 2009/7/15

N2 - A rapid array-based protocol is presented by which a modest affinity protein-binding small molecule can be appended to a library of peptoids via click chemistry. The array can then be screened for improved ligands that exhibit a higher affinity for the protein target.

AB - A rapid array-based protocol is presented by which a modest affinity protein-binding small molecule can be appended to a library of peptoids via click chemistry. The array can then be screened for improved ligands that exhibit a higher affinity for the protein target.

KW - Click chemistry

KW - Combinatorial chemistry

KW - Library screening

KW - Microarray

KW - Peptoid

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JO - Bioorganic and Medicinal Chemistry Letters

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ER -

Rapid identification of improved protein ligands using peptoid microarrays

Abstract

Keywords

ASJC Scopus subject areas

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