Rapidly evolving adeno-associated virus vectors: Increasing possibility of gene therapy with custom-made vectors

Hiroyuki Nakai

doi:10.2745/dds.24.582

Rapidly evolving adeno-associated virus vectors: Increasing possibility of gene therapy with custom-made vectors

Research output: Contribution to journal › Article › peer-review

Abstract

Nature has evolved adeno-associated viruses (AAVs) very slowly by natural selection in their long history. However, since over 100 AAV serotypes and variants were discovered in primates in 2002, their evolution has been significantly accelerated by human intervention. Their simplest structure and ease of genetic manipulation have allowed exploitation of rational design and directed evolution approaches to create AAVs with desired properties. It has become possible to create custom-made AAV vectors for various experimental and therapeutic purposes.

Original language	English (US)
Pages (from-to)	582-591
Number of pages	10
Journal	Drug Delivery System
Volume	24
Issue number	6
DOIs	https://doi.org/10.2745/dds.24.582
State	Published - 2009
Externally published	Yes

Keywords

Adeno-associated virus
Custom-made vector
DNA shuffling
Gene therapy
Random peptide display

ASJC Scopus subject areas

Pharmaceutical Science

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10.2745/dds.24.582

Cite this

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abstract = "Nature has evolved adeno-associated viruses (AAVs) very slowly by natural selection in their long history. However, since over 100 AAV serotypes and variants were discovered in primates in 2002, their evolution has been significantly accelerated by human intervention. Their simplest structure and ease of genetic manipulation have allowed exploitation of rational design and directed evolution approaches to create AAVs with desired properties. It has become possible to create custom-made AAV vectors for various experimental and therapeutic purposes.",

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Rapidly evolving adeno-associated virus vectors: Increasing possibility of gene therapy with custom-made vectors

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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