TY - GEN
T1 - Reconstructability analysis of genetic loci associated with Alzheimer disease
AU - Kramer, Patricia
AU - Westaway, Shawn K.
AU - Zwick, Martin
AU - Shervais, Stephen
PY - 2012
Y1 - 2012
N2 - Reconstructability Analysis (RA) is an information-and graph-theory-based method which has been successfully used in previous genomic studies. Here we apply it to genetic (14 SNPs) and non-genetic (Education, Age, Gender) data on Alzheimer disease in a well-characterized Case/Control sample of 424 individuals. We confirm the importance of APOE as a predictor of the disease, and identify one non-genetic factor, Education, and two SNPs, one in BINI and the other in SORCS1, as likely disease predictors. SORCS1 appears to be a common risk factor for people with or without APOE. We also identify a possible interaction effect between Education and BINI. Methodologically, we introduce and use to advantage some more powerful features of RA not used in prior genomic studies.
AB - Reconstructability Analysis (RA) is an information-and graph-theory-based method which has been successfully used in previous genomic studies. Here we apply it to genetic (14 SNPs) and non-genetic (Education, Age, Gender) data on Alzheimer disease in a well-characterized Case/Control sample of 424 individuals. We confirm the importance of APOE as a predictor of the disease, and identify one non-genetic factor, Education, and two SNPs, one in BINI and the other in SORCS1, as likely disease predictors. SORCS1 appears to be a common risk factor for people with or without APOE. We also identify a possible interaction effect between Education and BINI. Methodologically, we introduce and use to advantage some more powerful features of RA not used in prior genomic studies.
KW - Alzheimer Disease
KW - OCCAM
KW - Reconstructability Analysis
KW - bioinformatics
KW - genetics
UR - http://www.scopus.com/inward/record.url?scp=84877797135&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84877797135&partnerID=8YFLogxK
U2 - 10.1109/SCIS-ISIS.2012.6505196
DO - 10.1109/SCIS-ISIS.2012.6505196
M3 - Conference contribution
AN - SCOPUS:84877797135
SN - 9781467327428
T3 - 6th International Conference on Soft Computing and Intelligent Systems, and 13th International Symposium on Advanced Intelligence Systems, SCIS/ISIS 2012
SP - 2104
EP - 2110
BT - 6th International Conference on Soft Computing and Intelligent Systems, and 13th International Symposium on Advanced Intelligence Systems, SCIS/ISIS 2012
T2 - 2012 Joint 6th International Conference on Soft Computing and Intelligent Systems, SCIS 2012 and 13th International Symposium on Advanced Intelligence Systems, ISIS 2012
Y2 - 20 November 2012 through 24 November 2012
ER -