Recreational cannabis use over time in individuals at clinical high risk for psychosis: Lack of associations with symptom, neurocognitive, functioning, and treatment patterns

Ricardo E. Carrión; Andrea M. Auther; Danielle McLaughlin; Steven Adelsheim; Cynthia Z. Burton; Cameron S. Carter; Tara Niendam; J. Daniel Ragland; Tamara G. Sale; Stephan F. Taylor; Ivy F. Tso; William R. McFarlane; Barbara A. Cornblatt

doi:10.1016/j.psychres.2023.115420

Recreational cannabis use over time in individuals at clinical high risk for psychosis: Lack of associations with symptom, neurocognitive, functioning, and treatment patterns

Ricardo E. Carrión, Andrea M. Auther, Danielle McLaughlin, Steven Adelsheim, Cynthia Z. Burton, Cameron S. Carter, Tara Niendam, J. Daniel Ragland, Tamara G. Sale, Stephan F. Taylor, Ivy F. Tso, William R. McFarlane, Barbara A. Cornblatt

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Recreational cannabis use has recently gained considerable interest as an environmental risk factor that triggers the onset of psychosis. To date, however, the evidence that cannabis is associated with negative outcomes in individuals at clinical high risk (CHR) for psychosis is inconsistent. The present study tracked cannabis usage over a 2-year period and examined its associations with clinical and neurocognitive outcomes, along with medication rates. CHR youth who continuously used cannabis had higher neurocognition and social functioning over time, and decreased medication usage, relative to non-users. Surprisingly, clinical symptoms improved over time despite the medication decreases.

Original language	English (US)
Article number	115420
Journal	Psychiatry Research
Volume	328
DOIs	https://doi.org/10.1016/j.psychres.2023.115420
State	Published - Oct 2023
Externally published	Yes

Keywords

Cannabis
Clinical high risk for psychosis
Prevention

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/j.psychres.2023.115420

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Carrión, R. E., Auther, A. M., McLaughlin, D., Adelsheim, S., Burton, C. Z., Carter, C. S., Niendam, T., Ragland, J. D., Sale, T. G., Taylor, S. F., Tso, I. F., McFarlane, W. R., & Cornblatt, B. A. (2023). Recreational cannabis use over time in individuals at clinical high risk for psychosis: Lack of associations with symptom, neurocognitive, functioning, and treatment patterns. Psychiatry Research, 328, Article 115420. https://doi.org/10.1016/j.psychres.2023.115420

Carrión, RE, Auther, AM, McLaughlin, D, Adelsheim, S, Burton, CZ, Carter, CS, Niendam, T, Ragland, JD, Sale, TG, Taylor, SF, Tso, IF, McFarlane, WR & Cornblatt, BA 2023, 'Recreational cannabis use over time in individuals at clinical high risk for psychosis: Lack of associations with symptom, neurocognitive, functioning, and treatment patterns', Psychiatry Research, vol. 328, 115420. https://doi.org/10.1016/j.psychres.2023.115420

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abstract = "Recreational cannabis use has recently gained considerable interest as an environmental risk factor that triggers the onset of psychosis. To date, however, the evidence that cannabis is associated with negative outcomes in individuals at clinical high risk (CHR) for psychosis is inconsistent. The present study tracked cannabis usage over a 2-year period and examined its associations with clinical and neurocognitive outcomes, along with medication rates. CHR youth who continuously used cannabis had higher neurocognition and social functioning over time, and decreased medication usage, relative to non-users. Surprisingly, clinical symptoms improved over time despite the medication decreases.",

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AU - McLaughlin, Danielle

AU - Adelsheim, Steven

AU - Burton, Cynthia Z.

AU - Carter, Cameron S.

AU - Niendam, Tara

AU - Ragland, J. Daniel

AU - Sale, Tamara G.

AU - Taylor, Stephan F.

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Recreational cannabis use over time in individuals at clinical high risk for psychosis: Lack of associations with symptom, neurocognitive, functioning, and treatment patterns

Abstract

Keywords

ASJC Scopus subject areas

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