Reduction of Amphotericin B Nephrotoxicity With Mannitol

Jeffrey M. Rosch, George J. Pazin, Philip Fireman

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Amphotericin B in combination with mannitol was given to a patient who had mucocutaneous candidiasis and moderate renal insufficiency. Previously, amphotericin B alone had induced an abrupt increase in serum creatinine and urea nitrogen, but when mannitol was given concurrently there was no worsening of renal function. Thus, amphotericin B with mannitol appears to offer a less nephrotoxic but equally candicidal therapeutic regimen in the renal compromised patient requiring parenteral candicidal therapy.

Original languageEnglish (US)
Pages (from-to)1995-1996
Number of pages2
JournalJAMA: The Journal of the American Medical Association
Issue number18
StatePublished - May 3 1976
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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