Referral and treatment patterns in pancreatic acinar cell carcinoma: A regional population-level analysis

Ranish K. Patel; Michael Parappilly; Thomas L. Sutton; Shay Behrens; Issac R. Schwantes; Alicia J. Johnson; Rodney F. Pommier; Brett C. Sheppard

doi:10.1016/j.amjsurg.2023.04.010

Referral and treatment patterns in pancreatic acinar cell carcinoma: A regional population-level analysis

Ranish K. Patel, Michael Parappilly, Thomas L. Sutton, Shay Behrens, Issac R. Schwantes, Alicia J. Johnson, Rodney F. Pommier, Brett C. Sheppard

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Background: Pancreatic acinar cell carcinoma (PACC) is a rare exocrine tumor of the pancreas. We evaluated the effect disease stage, surgical intervention, and institutional volume status plays in survival. Methods: We queried the Oregon State Cancer Registry for patients with PACC from 1997 to 2018. Treatment and referral patterns were analyzed, and overall survival (OS) was evaluated with Kaplan-Meier and Cox-proportional hazard analysis. Results: 43 patients were identified. Median OS was 33.1 and 7.1 months in those with locoregional and metastatic disease respectively (p = 0.008). Surgical intervention was associated with improved OS (hazard ratio 0.28, p < 0.0001). High volume center (HVC) care trended towards improving OS. While the majority of cases were diagnosed at low volume centers (74%), referral to HVCs was rare (n = 4) and limited to advanced (stage III/IV) disease. Conclusion: Stage and surgical resection influence survival outcomes in PACC, more data is needed to delineate the impact of institutional volume status.

Original language	English (US)
Journal	American journal of surgery
DOIs	https://doi.org/10.1016/j.amjsurg.2023.04.010
State	Accepted/In press - 2023

Keywords

Acinar cell carcinoma
Pancreas
Referral center
Surgical resection
Survival
Treatment patterns

ASJC Scopus subject areas

Surgery

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10.1016/j.amjsurg.2023.04.010

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@article{6f7879e9ff6d4ceab29ff38462989477,

title = "Referral and treatment patterns in pancreatic acinar cell carcinoma: A regional population-level analysis",

abstract = "Background: Pancreatic acinar cell carcinoma (PACC) is a rare exocrine tumor of the pancreas. We evaluated the effect disease stage, surgical intervention, and institutional volume status plays in survival. Methods: We queried the Oregon State Cancer Registry for patients with PACC from 1997 to 2018. Treatment and referral patterns were analyzed, and overall survival (OS) was evaluated with Kaplan-Meier and Cox-proportional hazard analysis. Results: 43 patients were identified. Median OS was 33.1 and 7.1 months in those with locoregional and metastatic disease respectively (p = 0.008). Surgical intervention was associated with improved OS (hazard ratio 0.28, p < 0.0001). High volume center (HVC) care trended towards improving OS. While the majority of cases were diagnosed at low volume centers (74%), referral to HVCs was rare (n = 4) and limited to advanced (stage III/IV) disease. Conclusion: Stage and surgical resection influence survival outcomes in PACC, more data is needed to delineate the impact of institutional volume status.",

keywords = "Acinar cell carcinoma, Pancreas, Referral center, Surgical resection, Survival, Treatment patterns",

author = "Patel, {Ranish K.} and Michael Parappilly and Sutton, {Thomas L.} and Shay Behrens and Schwantes, {Issac R.} and Johnson, {Alicia J.} and Pommier, {Rodney F.} and Sheppard, {Brett C.}",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier Inc.",

year = "2023",

doi = "10.1016/j.amjsurg.2023.04.010",

language = "English (US)",

journal = "American journal of surgery",

issn = "0002-9610",

publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Referral and treatment patterns in pancreatic acinar cell carcinoma

T2 - A regional population-level analysis

AU - Patel, Ranish K.

AU - Parappilly, Michael

AU - Sutton, Thomas L.

AU - Behrens, Shay

AU - Schwantes, Issac R.

AU - Johnson, Alicia J.

AU - Pommier, Rodney F.

AU - Sheppard, Brett C.

PY - 2023

Y1 - 2023

N2 - Background: Pancreatic acinar cell carcinoma (PACC) is a rare exocrine tumor of the pancreas. We evaluated the effect disease stage, surgical intervention, and institutional volume status plays in survival. Methods: We queried the Oregon State Cancer Registry for patients with PACC from 1997 to 2018. Treatment and referral patterns were analyzed, and overall survival (OS) was evaluated with Kaplan-Meier and Cox-proportional hazard analysis. Results: 43 patients were identified. Median OS was 33.1 and 7.1 months in those with locoregional and metastatic disease respectively (p = 0.008). Surgical intervention was associated with improved OS (hazard ratio 0.28, p < 0.0001). High volume center (HVC) care trended towards improving OS. While the majority of cases were diagnosed at low volume centers (74%), referral to HVCs was rare (n = 4) and limited to advanced (stage III/IV) disease. Conclusion: Stage and surgical resection influence survival outcomes in PACC, more data is needed to delineate the impact of institutional volume status.

AB - Background: Pancreatic acinar cell carcinoma (PACC) is a rare exocrine tumor of the pancreas. We evaluated the effect disease stage, surgical intervention, and institutional volume status plays in survival. Methods: We queried the Oregon State Cancer Registry for patients with PACC from 1997 to 2018. Treatment and referral patterns were analyzed, and overall survival (OS) was evaluated with Kaplan-Meier and Cox-proportional hazard analysis. Results: 43 patients were identified. Median OS was 33.1 and 7.1 months in those with locoregional and metastatic disease respectively (p = 0.008). Surgical intervention was associated with improved OS (hazard ratio 0.28, p < 0.0001). High volume center (HVC) care trended towards improving OS. While the majority of cases were diagnosed at low volume centers (74%), referral to HVCs was rare (n = 4) and limited to advanced (stage III/IV) disease. Conclusion: Stage and surgical resection influence survival outcomes in PACC, more data is needed to delineate the impact of institutional volume status.

KW - Acinar cell carcinoma

KW - Pancreas

KW - Referral center

KW - Surgical resection

KW - Survival

KW - Treatment patterns

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U2 - 10.1016/j.amjsurg.2023.04.010

DO - 10.1016/j.amjsurg.2023.04.010

M3 - Article

AN - SCOPUS:85152890814

SN - 0002-9610

JO - American journal of surgery

JF - American journal of surgery

ER -

Referral and treatment patterns in pancreatic acinar cell carcinoma: A regional population-level analysis

Abstract

Keywords

ASJC Scopus subject areas

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