Referral and treatment patterns in pancreatic acinar cell carcinoma: A regional population-level analysis

Ranish K. Patel; Michael Parappilly; Thomas L. Sutton; Shay Behrens; Issac R. Schwantes; Alicia J. Johnson; Rodney F. Pommier; Brett C. Sheppard

doi:10.1016/j.amjsurg.2023.04.010

Referral and treatment patterns in pancreatic acinar cell carcinoma: A regional population-level analysis

Ranish K. Patel, Michael Parappilly, Thomas L. Sutton, Shay Behrens, Issac R. Schwantes, Alicia J. Johnson, Rodney F. Pommier, Brett C. Sheppard

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Background: Pancreatic acinar cell carcinoma (PACC) is a rare exocrine tumor of the pancreas. We evaluated the effect disease stage, surgical intervention, and institutional volume status plays in survival. Methods: We queried the Oregon State Cancer Registry for patients with PACC from 1997 to 2018. Treatment and referral patterns were analyzed, and overall survival (OS) was evaluated with Kaplan-Meier and Cox-proportional hazard analysis. Results: 43 patients were identified. Median OS was 33.1 and 7.1 months in those with locoregional and metastatic disease respectively (p = 0.008). Surgical intervention was associated with improved OS (hazard ratio 0.28, p < 0.0001). High volume center (HVC) care trended towards improving OS. While the majority of cases were diagnosed at low volume centers (74%), referral to HVCs was rare (n = 4) and limited to advanced (stage III/IV) disease. Conclusion: Stage and surgical resection influence survival outcomes in PACC, more data is needed to delineate the impact of institutional volume status.

Original language	English (US)
Pages (from-to)	55-59
Number of pages	5
Journal	American journal of surgery
Volume	231
DOIs	https://doi.org/10.1016/j.amjsurg.2023.04.010
State	Published - May 2024

Keywords

Acinar cell carcinoma
Pancreas
Referral center
Surgical resection
Survival
Treatment patterns

ASJC Scopus subject areas

Surgery

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10.1016/j.amjsurg.2023.04.010

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@article{6f7879e9ff6d4ceab29ff38462989477,

title = "Referral and treatment patterns in pancreatic acinar cell carcinoma: A regional population-level analysis",

abstract = "Background: Pancreatic acinar cell carcinoma (PACC) is a rare exocrine tumor of the pancreas. We evaluated the effect disease stage, surgical intervention, and institutional volume status plays in survival. Methods: We queried the Oregon State Cancer Registry for patients with PACC from 1997 to 2018. Treatment and referral patterns were analyzed, and overall survival (OS) was evaluated with Kaplan-Meier and Cox-proportional hazard analysis. Results: 43 patients were identified. Median OS was 33.1 and 7.1 months in those with locoregional and metastatic disease respectively (p = 0.008). Surgical intervention was associated with improved OS (hazard ratio 0.28, p < 0.0001). High volume center (HVC) care trended towards improving OS. While the majority of cases were diagnosed at low volume centers (74%), referral to HVCs was rare (n = 4) and limited to advanced (stage III/IV) disease. Conclusion: Stage and surgical resection influence survival outcomes in PACC, more data is needed to delineate the impact of institutional volume status.",

keywords = "Acinar cell carcinoma, Pancreas, Referral center, Surgical resection, Survival, Treatment patterns",

author = "Patel, {Ranish K.} and Michael Parappilly and Sutton, {Thomas L.} and Shay Behrens and Schwantes, {Issac R.} and Johnson, {Alicia J.} and Pommier, {Rodney F.} and Sheppard, {Brett C.}",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier Inc.",

year = "2024",

month = may,

doi = "10.1016/j.amjsurg.2023.04.010",

language = "English (US)",

volume = "231",

pages = "55--59",

journal = "American journal of surgery",

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publisher = "Elsevier Inc.",

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TY - JOUR

T1 - Referral and treatment patterns in pancreatic acinar cell carcinoma

T2 - A regional population-level analysis

AU - Patel, Ranish K.

AU - Parappilly, Michael

AU - Sutton, Thomas L.

AU - Behrens, Shay

AU - Schwantes, Issac R.

AU - Johnson, Alicia J.

AU - Pommier, Rodney F.

AU - Sheppard, Brett C.

PY - 2024/5

Y1 - 2024/5

N2 - Background: Pancreatic acinar cell carcinoma (PACC) is a rare exocrine tumor of the pancreas. We evaluated the effect disease stage, surgical intervention, and institutional volume status plays in survival. Methods: We queried the Oregon State Cancer Registry for patients with PACC from 1997 to 2018. Treatment and referral patterns were analyzed, and overall survival (OS) was evaluated with Kaplan-Meier and Cox-proportional hazard analysis. Results: 43 patients were identified. Median OS was 33.1 and 7.1 months in those with locoregional and metastatic disease respectively (p = 0.008). Surgical intervention was associated with improved OS (hazard ratio 0.28, p < 0.0001). High volume center (HVC) care trended towards improving OS. While the majority of cases were diagnosed at low volume centers (74%), referral to HVCs was rare (n = 4) and limited to advanced (stage III/IV) disease. Conclusion: Stage and surgical resection influence survival outcomes in PACC, more data is needed to delineate the impact of institutional volume status.

AB - Background: Pancreatic acinar cell carcinoma (PACC) is a rare exocrine tumor of the pancreas. We evaluated the effect disease stage, surgical intervention, and institutional volume status plays in survival. Methods: We queried the Oregon State Cancer Registry for patients with PACC from 1997 to 2018. Treatment and referral patterns were analyzed, and overall survival (OS) was evaluated with Kaplan-Meier and Cox-proportional hazard analysis. Results: 43 patients were identified. Median OS was 33.1 and 7.1 months in those with locoregional and metastatic disease respectively (p = 0.008). Surgical intervention was associated with improved OS (hazard ratio 0.28, p < 0.0001). High volume center (HVC) care trended towards improving OS. While the majority of cases were diagnosed at low volume centers (74%), referral to HVCs was rare (n = 4) and limited to advanced (stage III/IV) disease. Conclusion: Stage and surgical resection influence survival outcomes in PACC, more data is needed to delineate the impact of institutional volume status.

KW - Acinar cell carcinoma

KW - Pancreas

KW - Referral center

KW - Surgical resection

KW - Survival

KW - Treatment patterns

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JO - American journal of surgery

JF - American journal of surgery

ER -

Referral and treatment patterns in pancreatic acinar cell carcinoma: A regional population-level analysis

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Keywords

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