Regional Analysis of Intact and Defective HIV Proviruses in the Brain of Viremic and Virally Suppressed People with HIV

Thomas A. Angelovich; Catherine R. Cochrane; Jingling Zhou; Carolin Tumpach; Sarah J. Byrnes; Janna Jamal Eddine; Emily Waring; Kathleen Busman-Sahay; Claire Deleage; Trisha A. Jenkins; Anna C. Hearps; Stuart Turville; Paul R. Gorry; Sharon R. Lewin; Bruce J. Brew; Jacob D. Estes; Michael Roche; Melissa J. Churchill

doi:10.1002/ana.26750

Regional Analysis of Intact and Defective HIV Proviruses in the Brain of Viremic and Virally Suppressed People with HIV

Thomas A. Angelovich, Catherine R. Cochrane, Jingling Zhou, Carolin Tumpach, Sarah J. Byrnes, Janna Jamal Eddine, Emily Waring, Kathleen Busman-Sahay, Claire Deleage, Trisha A. Jenkins, Anna C. Hearps, Stuart Turville, Paul R. Gorry, Sharon R. Lewin, Bruce J. Brew, Jacob D. Estes, Michael Roche, Melissa J. Churchill

Vaccine and Gene Therapy Institute

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Here, we provide the first regional analysis of intact and defective HIV reservoirs within the brain. Brain tissue from both viremic and virally suppressed people with HIV (PWH) harbored HIV pol DNA in all regions tested, with lower levels present in basal ganglia and cerebellum relative to frontal white matter. Intact proviruses were primarily found in the frontal white matter but also detected in other brain regions of PWH, demonstrating frontal white matter as a major brain reservoir of intact, potentially replication competent HIV DNA that persists despite antiretroviral therapy. ANN NEUROL 2023;94:798–802.

Original language	English (US)
Pages (from-to)	798-802
Number of pages	5
Journal	Annals of Neurology
Volume	94
Issue number	4
DOIs	https://doi.org/10.1002/ana.26750
State	Published - Oct 2023

ASJC Scopus subject areas

Neurology
Clinical Neurology

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Angelovich, T. A., Cochrane, C. R., Zhou, J., Tumpach, C., Byrnes, S. J., Jamal Eddine, J., Waring, E., Busman-Sahay, K., Deleage, C., Jenkins, T. A., Hearps, A. C., Turville, S., Gorry, P. R., Lewin, S. R., Brew, B. J., Estes, J. D., Roche, M., & Churchill, M. J. (2023). Regional Analysis of Intact and Defective HIV Proviruses in the Brain of Viremic and Virally Suppressed People with HIV. Annals of Neurology, 94(4), 798-802. https://doi.org/10.1002/ana.26750

Angelovich, TA, Cochrane, CR, Zhou, J, Tumpach, C, Byrnes, SJ, Jamal Eddine, J, Waring, E, Busman-Sahay, K, Deleage, C, Jenkins, TA, Hearps, AC, Turville, S, Gorry, PR, Lewin, SR, Brew, BJ, Estes, JD, Roche, M & Churchill, MJ 2023, 'Regional Analysis of Intact and Defective HIV Proviruses in the Brain of Viremic and Virally Suppressed People with HIV', Annals of Neurology, vol. 94, no. 4, pp. 798-802. https://doi.org/10.1002/ana.26750

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abstract = "Here, we provide the first regional analysis of intact and defective HIV reservoirs within the brain. Brain tissue from both viremic and virally suppressed people with HIV (PWH) harbored HIV pol DNA in all regions tested, with lower levels present in basal ganglia and cerebellum relative to frontal white matter. Intact proviruses were primarily found in the frontal white matter but also detected in other brain regions of PWH, demonstrating frontal white matter as a major brain reservoir of intact, potentially replication competent HIV DNA that persists despite antiretroviral therapy. ANN NEUROL 2023;94:798–802.",

author = "Angelovich, {Thomas A.} and Cochrane, {Catherine R.} and Jingling Zhou and Carolin Tumpach and Byrnes, {Sarah J.} and {Jamal Eddine}, Janna and Emily Waring and Kathleen Busman-Sahay and Claire Deleage and Jenkins, {Trisha A.} and Hearps, {Anna C.} and Stuart Turville and Gorry, {Paul R.} and Lewin, {Sharon R.} and Brew, {Bruce J.} and Estes, {Jacob D.} and Michael Roche and Churchill, {Melissa J.}",

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AU - Zhou, Jingling

AU - Tumpach, Carolin

AU - Byrnes, Sarah J.

AU - Jamal Eddine, Janna

AU - Waring, Emily

AU - Busman-Sahay, Kathleen

AU - Deleage, Claire

AU - Jenkins, Trisha A.

AU - Hearps, Anna C.

AU - Turville, Stuart

AU - Gorry, Paul R.

AU - Lewin, Sharon R.

AU - Brew, Bruce J.

AU - Estes, Jacob D.

AU - Roche, Michael

AU - Churchill, Melissa J.

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AB - Here, we provide the first regional analysis of intact and defective HIV reservoirs within the brain. Brain tissue from both viremic and virally suppressed people with HIV (PWH) harbored HIV pol DNA in all regions tested, with lower levels present in basal ganglia and cerebellum relative to frontal white matter. Intact proviruses were primarily found in the frontal white matter but also detected in other brain regions of PWH, demonstrating frontal white matter as a major brain reservoir of intact, potentially replication competent HIV DNA that persists despite antiretroviral therapy. ANN NEUROL 2023;94:798–802.

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Regional Analysis of Intact and Defective HIV Proviruses in the Brain of Viremic and Virally Suppressed People with HIV

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