Regional differences in resting extracellular potassium levels of rat brain

Bita Moghaddam; Ralph N. Adams

doi:10.1016/0006-8993(87)90803-1

Regional differences in resting extracellular potassium levels of rat brain

Bita Moghaddam, Ralph N. Adams

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

The extracellular potassium concentration in the cerebral cortex of the mammalian brain has been repeatedly reported to be approximately 3.0 mM. We have made detailed measurements with potassium-selective microelectrodes and have found significantly lower extracellular potassium concentrations in unstimulated rat brain caudate and thalamus (1.9-2.5 mM) when compared to cortex and cerebral spinal fluid (3.0-3.5 mM). These regional differences may be caused by variations in spontaneous activity of neurons, regional permeability differences in endothelial cells of brain capillaries to potassium, or caused by variations in uptake by glia.

Original language	English (US)
Pages (from-to)	337-340
Number of pages	4
Journal	Brain research
Volume	406
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(87)90803-1
State	Published - Mar 17 1987
Externally published	Yes

Keywords

Brain ionic homeostasis
Ion-selective microelectrode
Potassium

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(87)90803-1

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title = "Regional differences in resting extracellular potassium levels of rat brain",

abstract = "The extracellular potassium concentration in the cerebral cortex of the mammalian brain has been repeatedly reported to be approximately 3.0 mM. We have made detailed measurements with potassium-selective microelectrodes and have found significantly lower extracellular potassium concentrations in unstimulated rat brain caudate and thalamus (1.9-2.5 mM) when compared to cortex and cerebral spinal fluid (3.0-3.5 mM). These regional differences may be caused by variations in spontaneous activity of neurons, regional permeability differences in endothelial cells of brain capillaries to potassium, or caused by variations in uptake by glia.",

keywords = "Brain ionic homeostasis, Ion-selective microelectrode, Potassium",

author = "Bita Moghaddam and Adams, {Ralph N.}",

note = "Funding Information: The authors wish to thank James Schenk and Tom Kent for helpful discussions and Ken Renner for technical assistance. This work was supported by NIH Grant NS08740 and a Javits Neuroscience Investigation Award to R.N,A.",

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AU - Moghaddam, Bita

AU - Adams, Ralph N.

N1 - Funding Information: The authors wish to thank James Schenk and Tom Kent for helpful discussions and Ken Renner for technical assistance. This work was supported by NIH Grant NS08740 and a Javits Neuroscience Investigation Award to R.N,A.

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Y1 - 1987/3/17

N2 - The extracellular potassium concentration in the cerebral cortex of the mammalian brain has been repeatedly reported to be approximately 3.0 mM. We have made detailed measurements with potassium-selective microelectrodes and have found significantly lower extracellular potassium concentrations in unstimulated rat brain caudate and thalamus (1.9-2.5 mM) when compared to cortex and cerebral spinal fluid (3.0-3.5 mM). These regional differences may be caused by variations in spontaneous activity of neurons, regional permeability differences in endothelial cells of brain capillaries to potassium, or caused by variations in uptake by glia.

AB - The extracellular potassium concentration in the cerebral cortex of the mammalian brain has been repeatedly reported to be approximately 3.0 mM. We have made detailed measurements with potassium-selective microelectrodes and have found significantly lower extracellular potassium concentrations in unstimulated rat brain caudate and thalamus (1.9-2.5 mM) when compared to cortex and cerebral spinal fluid (3.0-3.5 mM). These regional differences may be caused by variations in spontaneous activity of neurons, regional permeability differences in endothelial cells of brain capillaries to potassium, or caused by variations in uptake by glia.

KW - Brain ionic homeostasis

KW - Ion-selective microelectrode

KW - Potassium

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Regional differences in resting extracellular potassium levels of rat brain

Abstract

Keywords

ASJC Scopus subject areas

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