Regionally selective atrophy of subcortical structures in prodromal HD as revealed by statistical shape analysis

Laurent Younes; J. Tilak Ratnanather; Timothy Brown; Elizabeth Aylward; Peg Nopoulos; Hans Johnson; Vincent A. Magnotta; Jane S. Paulsen; Russell L. Margolis; Roger L. Albin; Michael I. Miller; Christopher A. Ross; Thomas Wassink; Stephen Cross; Mycah Kimble; Patricia Ryan; Eric A. Epping; Edmond Chiu; Olga Yastrubetskaya; Joy Preston; Anita Goh; D. Psych; Stephanie Antonopoulos; Samantha Loi; Phyllis Chua; Angela Komiti; Lynn Raymond; Joji Decolongon; Mark Varvaris; William M. Mallonee; Greg Suter; Ali Samii; Alma Macaraeg; Randi Jones; Cathy Wood-Siverio; Stewart A. Factor; Claudia Testa; Roger A. Barker; Sarah Mason; Elizabeth McCusker; Jane Griffith; Clement Loy; David Gunn; Michael Orth; Sigurd Sübmuth; Katrin Barth; Sonja Trautmann; Kimberly Quaid; Melissa Wesson; Joanne Wojcieszek; Mark Guttman; Alanna Sheinberg; Irita Karmalkar; Susan Perlman; Brian Clemente; Michael D. Geschwind; Gail Kang; Gabriela Satris; Tom Warner; Maggie Burrows; Anne Rosser; Kathy Price; Sarah Hunt; Frederick Marshall; Amy Chesire; Mary Wodarski; Charlyne Hickey; Peter Panegyres; Joseph Lee; Steve Andrew; Joel Perlmutter; Stacey Barton; Amy Schmidt; Zosia Miedzybrodzka; Daniela Rae; Mariella D'Alessandro; David Craufurd; Judith Bek; Elizabeth Howard; Pietro Mazzoni; Karen Marder; Paula Wasserman; Rajeev Kumar; Diane Erickson; Vicki Wheelock; Terry Tempkin; Lisa Kjer; Wayne Martin; Pamela King; Marguerite Wieler; Satwinder Sran; Oksana Suchowersky; Anwar Ahmed; Stephen Rao; Christine Reece; Alex Bura; Lyla Mourany; Juliet Schulz; Jeffrey D. Long; Kelsey Montross; Jeremy Bockholt; Steve Blanchard; Ken Evans; Wayne Matson; Asa Peterson; James A. Mills; Jean Paul Vonsattel; Carol Moskowitz; Stacie Vik; Deborah Harrington; Gabriel Castillo; Jessica Morison; Jason Reed; Michael Diaz; Ian Dobbins; Tamara Hershey; Erin Foster; Deborah Moore; Holly Westervelt; Jennifer Davis; Geoff Tremont; J. David; Carissa Gehl; Kirsty Matheson; Karen Siedlecki; Marleen Van Walsem; Greg Elias; Mary Gover; Rachel Bernier; Noelle Carlozzi; Kevin Duff; Georgiou-Karistianis Nellie Georgiou-Karistianis; Kate Papp; Janet Willia; Lee Anna Clark; Nancy Downing; Michelle Harreld; Rebecca Ready; Anthony Vaccarino; Sarah Farias; Marcy MacDonald; Jim Gusella; Rick Myers; Christopher Ross; Kathy Jones; Jacquie Marietta; Greg Harris; Eun Young Kim; Greg Ennis; John Ashburner; Steve Potkin; Arthur Toga; Eric Axelson; Sarah Reading; Mirza Faisal Beg; Karl Helmer; Kelvin Lim; Mark Lowe; Sasumu Mori; Allen Song; Jessica Turner; Erik Beall; Katherine Koenig; Michael Phillips; Jan Zimbelman; Jess Fiedorowicz; Robert Robinson; Megan Smith; Leigh Beglinger; Janet Williams; Dawei Liu; David Moser; Kelly Rowe; Karen Anderson; Mark Groves; Hugh Rickards; Eric Van Duijn; Ji In Kim; Ying Zhang; Wenjing Lu; Craig Stout; Spencer Lourens; Martha Nance; Sean Thompson; Cheryl Erwin; Lisa Hughes; Jim Smith; Roland Zschiegner; Ryan Wyse; Owen Wade; Derek Weston; Chris Werling-Witkoske; Karla Anderson; Brittany Lichty; Leann Davis; Phil Danzer

doi:10.1002/hbm.22214

Regionally selective atrophy of subcortical structures in prodromal HD as revealed by statistical shape analysis

Laurent Younes, J. Tilak Ratnanather, Timothy Brown, Elizabeth Aylward, Peg Nopoulos, Hans Johnson, Vincent A. Magnotta, Jane S. Paulsen, Russell L. Margolis, Roger L. Albin, Michael I. Miller, Christopher A. Ross, Thomas Wassink, Stephen Cross, Mycah Kimble, Patricia Ryan, Eric A. Epping, Edmond Chiu, Olga Yastrubetskaya, Joy PrestonAnita Goh, D. Psych, Stephanie Antonopoulos, Samantha Loi, Phyllis Chua, Angela Komiti, Lynn Raymond, Joji Decolongon, Mark Varvaris, William M. Mallonee, Greg Suter, Ali Samii, Alma Macaraeg, Randi Jones, Cathy Wood-Siverio, Stewart A. Factor, Claudia Testa, Roger A. Barker, Sarah Mason, Elizabeth McCusker, Jane Griffith, Clement Loy, David Gunn, Michael Orth, Sigurd Sübmuth, Katrin Barth, Sonja Trautmann, Kimberly Quaid, Melissa Wesson, Joanne Wojcieszek, Mark Guttman, Alanna Sheinberg, Irita Karmalkar, Susan Perlman, Brian Clemente, Michael D. Geschwind, Gail Kang, Gabriela Satris, Tom Warner, Maggie Burrows, Anne Rosser, Kathy Price, Sarah Hunt, Frederick Marshall, Amy Chesire, Mary Wodarski, Charlyne Hickey, Peter Panegyres, Joseph Lee, Steve Andrew, Joel Perlmutter, Stacey Barton, Amy Schmidt, Zosia Miedzybrodzka, Daniela Rae, Mariella D'Alessandro, David Craufurd, Judith Bek, Elizabeth Howard, Pietro Mazzoni, Karen Marder, Paula Wasserman, Rajeev Kumar, Diane Erickson, Vicki Wheelock, Terry Tempkin, Lisa Kjer, Wayne Martin, Pamela King, Marguerite Wieler, Satwinder Sran, Oksana Suchowersky, Anwar Ahmed, Stephen Rao, Christine Reece, Alex Bura, Lyla Mourany, Juliet Schulz, Jeffrey D. Long, Kelsey Montross, Jeremy Bockholt, Steve Blanchard, Ken Evans, Wayne Matson, Asa Peterson, James A. Mills, Jean Paul Vonsattel, Carol Moskowitz, Stacie Vik, Deborah Harrington, Gabriel Castillo, Jessica Morison, Jason Reed, Michael Diaz, Ian Dobbins, Tamara Hershey, Erin Foster, Deborah Moore, Holly Westervelt, Jennifer Davis, Geoff Tremont, J. David, Carissa Gehl, Kirsty Matheson, Karen Siedlecki, Marleen Van Walsem, Greg Elias, Mary Gover, Rachel Bernier, Noelle Carlozzi, Kevin Duff, Georgiou-Karistianis Nellie Georgiou-Karistianis, Kate Papp, Janet Willia, Lee Anna Clark, Nancy Downing, Michelle Harreld, Rebecca Ready, Anthony Vaccarino, Sarah Farias, Marcy MacDonald, Jim Gusella, Rick Myers, Christopher Ross, Kathy Jones, Jacquie Marietta, Greg Harris, Eun Young Kim, Greg Ennis, John Ashburner, Steve Potkin, Arthur Toga, Eric Axelson, Sarah Reading, Mirza Faisal Beg, Karl Helmer, Kelvin Lim, Mark Lowe, Sasumu Mori, Allen Song, Jessica Turner, Erik Beall, Katherine Koenig, Michael Phillips, Jan Zimbelman, Jess Fiedorowicz, Robert Robinson, Megan Smith, Leigh Beglinger, Janet Williams, Dawei Liu, David Moser, Kelly Rowe, Karen Anderson, Mark Groves, Hugh Rickards, Eric Van Duijn, Ji In Kim, Ying Zhang, Wenjing Lu, Craig Stout, Spencer Lourens, Martha Nance, Sean Thompson, Cheryl Erwin, Lisa Hughes, Jim Smith, Roland Zschiegner, Ryan Wyse, Owen Wade, Derek Weston, Chris Werling-Witkoske, Karla Anderson, Brittany Lichty, Leann Davis, Phil Danzer

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

Huntington disease (HD) is a neurodegenerative disorder that involves preferential atrophy in the striatal complex and related subcortical nuclei. In this article, which is based on a dataset extracted from the PREDICT-HD study, we use statistical shape analysis with deformation markers obtained through "Large Deformation Diffeomorphic Metric Mapping" of cortical surfaces to highlight specific atrophy patterns in the caudate, putamen, and globus pallidus, at different prodromal stages of the disease. On the basis of the relation to cortico-basal ganglia circuitry, we propose that statistical shape analysis, along with other structural and functional imaging studies, may help expand our understanding of the brain circuitry affected and other aspects of the neurobiology of HD, and also guide the most effective strategies for intervention.

Original language	English (US)
Pages (from-to)	792-809
Number of pages	18
Journal	Human Brain Mapping
Volume	35
Issue number	3
DOIs	https://doi.org/10.1002/hbm.22214
State	Published - Mar 1 2014
Externally published	Yes

Keywords

Diffeomorphic mapping
Pallidus atrophy
Striatal atrophy
Surface registration
Surface-based morphometry

ASJC Scopus subject areas

Anatomy
Radiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging
Neurology
Clinical Neurology

Access to Document

10.1002/hbm.22214

Cite this

Younes, L., Ratnanather, J. T., Brown, T., Aylward, E., Nopoulos, P., Johnson, H., Magnotta, V. A., Paulsen, J. S., Margolis, R. L., Albin, R. L., Miller, M. I., Ross, C. A., Wassink, T., Cross, S., Kimble, M., Ryan, P., Epping, E. A., Chiu, E., Yastrubetskaya, O., ... Danzer, P. (2014). Regionally selective atrophy of subcortical structures in prodromal HD as revealed by statistical shape analysis. Human Brain Mapping, 35(3), 792-809. https://doi.org/10.1002/hbm.22214

Younes, L, Ratnanather, JT, Brown, T, Aylward, E, Nopoulos, P, Johnson, H, Magnotta, VA, Paulsen, JS, Margolis, RL, Albin, RL, Miller, MI, Ross, CA, Wassink, T, Cross, S, Kimble, M, Ryan, P, Epping, EA, Chiu, E, Yastrubetskaya, O, Preston, J, Goh, A, Psych, D, Antonopoulos, S, Loi, S, Chua, P, Komiti, A, Raymond, L, Decolongon, J, Varvaris, M, Mallonee, WM, Suter, G, Samii, A, Macaraeg, A, Jones, R, Wood-Siverio, C, Factor, SA, Testa, C, Barker, RA, Mason, S, McCusker, E, Griffith, J, Loy, C, Gunn, D, Orth, M, Sübmuth, S, Barth, K, Trautmann, S, Quaid, K, Wesson, M, Wojcieszek, J, Guttman, M, Sheinberg, A, Karmalkar, I, Perlman, S, Clemente, B, Geschwind, MD, Kang, G, Satris, G, Warner, T, Burrows, M, Rosser, A, Price, K, Hunt, S, Marshall, F, Chesire, A, Wodarski, M, Hickey, C, Panegyres, P, Lee, J, Andrew, S, Perlmutter, J, Barton, S, Schmidt, A, Miedzybrodzka, Z, Rae, D, D'Alessandro, M, Craufurd, D, Bek, J, Howard, E, Mazzoni, P, Marder, K, Wasserman, P, Kumar, R, Erickson, D, Wheelock, V, Tempkin, T, Kjer, L, Martin, W, King, P, Wieler, M, Sran, S, Suchowersky, O, Ahmed, A, Rao, S, Reece, C, Bura, A, Mourany, L, Schulz, J, Long, JD, Montross, K, Bockholt, J, Blanchard, S, Evans, K, Matson, W, Peterson, A, Mills, JA, Vonsattel, JP, Moskowitz, C, Vik, S, Harrington, D, Castillo, G, Morison, J, Reed, J, Diaz, M, Dobbins, I, Hershey, T, Foster, E, Moore, D, Westervelt, H, Davis, J, Tremont, G, David, J, Gehl, C, Matheson, K, Siedlecki, K, Walsem, MV, Elias, G, Gover, M, Bernier, R, Carlozzi, N, Duff, K, Nellie Georgiou-Karistianis, G-K, Papp, K, Willia, J, Clark, LA, Downing, N, Harreld, M, Ready, R, Vaccarino, A, Farias, S, MacDonald, M, Gusella, J, Myers, R, Ross, C, Jones, K, Marietta, J, Harris, G, Kim, EY, Ennis, G, Ashburner, J, Potkin, S, Toga, A, Axelson, E, Reading, S, Beg, MF, Helmer, K, Lim, K, Lowe, M, Mori, S, Song, A, Turner, J, Beall, E, Koenig, K, Phillips, M, Zimbelman, J, Fiedorowicz, J, Robinson, R, Smith, M, Beglinger, L, Williams, J, Liu, D, Moser, D, Rowe, K, Anderson, K, Groves, M, Rickards, H, Van Duijn, E, Kim, JI, Zhang, Y, Lu, W, Stout, C, Lourens, S, Nance, M, Thompson, S, Erwin, C, Hughes, L, Smith, J, Zschiegner, R, Wyse, R, Wade, O, Weston, D, Werling-Witkoske, C, Anderson, K, Lichty, B, Davis, L & Danzer, P 2014, 'Regionally selective atrophy of subcortical structures in prodromal HD as revealed by statistical shape analysis', Human Brain Mapping, vol. 35, no. 3, pp. 792-809. https://doi.org/10.1002/hbm.22214

@article{b14092d5dd9046568eb09095d690bc91,

title = "Regionally selective atrophy of subcortical structures in prodromal HD as revealed by statistical shape analysis",

abstract = "Huntington disease (HD) is a neurodegenerative disorder that involves preferential atrophy in the striatal complex and related subcortical nuclei. In this article, which is based on a dataset extracted from the PREDICT-HD study, we use statistical shape analysis with deformation markers obtained through {"}Large Deformation Diffeomorphic Metric Mapping{"} of cortical surfaces to highlight specific atrophy patterns in the caudate, putamen, and globus pallidus, at different prodromal stages of the disease. On the basis of the relation to cortico-basal ganglia circuitry, we propose that statistical shape analysis, along with other structural and functional imaging studies, may help expand our understanding of the brain circuitry affected and other aspects of the neurobiology of HD, and also guide the most effective strategies for intervention.",

keywords = "Diffeomorphic mapping, Pallidus atrophy, Striatal atrophy, Surface registration, Surface-based morphometry",

author = "Laurent Younes and Ratnanather, {J. Tilak} and Timothy Brown and Elizabeth Aylward and Peg Nopoulos and Hans Johnson and Magnotta, {Vincent A.} and Paulsen, {Jane S.} and Margolis, {Russell L.} and Albin, {Roger L.} and Miller, {Michael I.} and Ross, {Christopher A.} and Thomas Wassink and Stephen Cross and Mycah Kimble and Patricia Ryan and Epping, {Eric A.} and Edmond Chiu and Olga Yastrubetskaya and Joy Preston and Anita Goh and D. Psych and Stephanie Antonopoulos and Samantha Loi and Phyllis Chua and Angela Komiti and Lynn Raymond and Joji Decolongon and Mark Varvaris and Mallonee, {William M.} and Greg Suter and Ali Samii and Alma Macaraeg and Randi Jones and Cathy Wood-Siverio and Factor, {Stewart A.} and Claudia Testa and Barker, {Roger A.} and Sarah Mason and Elizabeth McCusker and Jane Griffith and Clement Loy and David Gunn and Michael Orth and Sigurd S{\"u}bmuth and Katrin Barth and Sonja Trautmann and Kimberly Quaid and Melissa Wesson and Joanne Wojcieszek and Mark Guttman and Alanna Sheinberg and Irita Karmalkar and Susan Perlman and Brian Clemente and Geschwind, {Michael D.} and Gail Kang and Gabriela Satris and Tom Warner and Maggie Burrows and Anne Rosser and Kathy Price and Sarah Hunt and Frederick Marshall and Amy Chesire and Mary Wodarski and Charlyne Hickey and Peter Panegyres and Joseph Lee and Steve Andrew and Joel Perlmutter and Stacey Barton and Amy Schmidt and Zosia Miedzybrodzka and Daniela Rae and Mariella D'Alessandro and David Craufurd and Judith Bek and Elizabeth Howard and Pietro Mazzoni and Karen Marder and Paula Wasserman and Rajeev Kumar and Diane Erickson and Vicki Wheelock and Terry Tempkin and Lisa Kjer and Wayne Martin and Pamela King and Marguerite Wieler and Satwinder Sran and Oksana Suchowersky and Anwar Ahmed and Stephen Rao and Christine Reece and Alex Bura and Lyla Mourany and Juliet Schulz and Long, {Jeffrey D.} and Kelsey Montross and Jeremy Bockholt and Steve Blanchard and Ken Evans and Wayne Matson and Asa Peterson and Mills, {James A.} and Vonsattel, {Jean Paul} and Carol Moskowitz and Stacie Vik and Deborah Harrington and Gabriel Castillo and Jessica Morison and Jason Reed and Michael Diaz and Ian Dobbins and Tamara Hershey and Erin Foster and Deborah Moore and Holly Westervelt and Jennifer Davis and Geoff Tremont and J. David and Carissa Gehl and Kirsty Matheson and Karen Siedlecki and Walsem, {Marleen Van} and Greg Elias and Mary Gover and Rachel Bernier and Noelle Carlozzi and Kevin Duff and {Nellie Georgiou-Karistianis}, Georgiou-Karistianis and Kate Papp and Janet Willia and Clark, {Lee Anna} and Nancy Downing and Michelle Harreld and Rebecca Ready and Anthony Vaccarino and Sarah Farias and Marcy MacDonald and Jim Gusella and Rick Myers and Christopher Ross and Kathy Jones and Jacquie Marietta and Greg Harris and Kim, {Eun Young} and Greg Ennis and John Ashburner and Steve Potkin and Arthur Toga and Eric Axelson and Sarah Reading and Beg, {Mirza Faisal} and Karl Helmer and Kelvin Lim and Mark Lowe and Sasumu Mori and Allen Song and Jessica Turner and Erik Beall and Katherine Koenig and Michael Phillips and Jan Zimbelman and Jess Fiedorowicz and Robert Robinson and Megan Smith and Leigh Beglinger and Janet Williams and Dawei Liu and David Moser and Kelly Rowe and Karen Anderson and Mark Groves and Hugh Rickards and {Van Duijn}, Eric and Kim, {Ji In} and Ying Zhang and Wenjing Lu and Craig Stout and Spencer Lourens and Martha Nance and Sean Thompson and Cheryl Erwin and Lisa Hughes and Jim Smith and Roland Zschiegner and Ryan Wyse and Owen Wade and Derek Weston and Chris Werling-Witkoske and Karla Anderson and Brittany Lichty and Leann Davis and Phil Danzer",

year = "2014",

month = mar,

day = "1",

doi = "10.1002/hbm.22214",

language = "English (US)",

volume = "35",

pages = "792--809",

journal = "Human Brain Mapping",

issn = "1065-9471",

publisher = "Wiley-Liss Inc.",

number = "3",

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TY - JOUR

T1 - Regionally selective atrophy of subcortical structures in prodromal HD as revealed by statistical shape analysis

AU - Younes, Laurent

AU - Ratnanather, J. Tilak

AU - Brown, Timothy

AU - Aylward, Elizabeth

AU - Nopoulos, Peg

AU - Johnson, Hans

AU - Magnotta, Vincent A.

AU - Paulsen, Jane S.

AU - Margolis, Russell L.

AU - Albin, Roger L.

AU - Miller, Michael I.

AU - Ross, Christopher A.

AU - Wassink, Thomas

AU - Cross, Stephen

AU - Kimble, Mycah

AU - Ryan, Patricia

AU - Epping, Eric A.

AU - Chiu, Edmond

AU - Yastrubetskaya, Olga

AU - Preston, Joy

AU - Goh, Anita

AU - Psych, D.

AU - Antonopoulos, Stephanie

AU - Loi, Samantha

AU - Chua, Phyllis

AU - Komiti, Angela

AU - Raymond, Lynn

AU - Decolongon, Joji

AU - Varvaris, Mark

AU - Mallonee, William M.

AU - Suter, Greg

AU - Samii, Ali

AU - Macaraeg, Alma

AU - Jones, Randi

AU - Wood-Siverio, Cathy

AU - Factor, Stewart A.

AU - Testa, Claudia

AU - Barker, Roger A.

AU - Mason, Sarah

AU - McCusker, Elizabeth

AU - Griffith, Jane

AU - Loy, Clement

AU - Gunn, David

AU - Orth, Michael

AU - Sübmuth, Sigurd

AU - Barth, Katrin

AU - Trautmann, Sonja

AU - Quaid, Kimberly

AU - Wesson, Melissa

AU - Wojcieszek, Joanne

AU - Guttman, Mark

AU - Sheinberg, Alanna

AU - Karmalkar, Irita

AU - Perlman, Susan

AU - Clemente, Brian

AU - Geschwind, Michael D.

AU - Kang, Gail

AU - Satris, Gabriela

AU - Warner, Tom

AU - Burrows, Maggie

AU - Rosser, Anne

AU - Price, Kathy

AU - Hunt, Sarah

AU - Marshall, Frederick

AU - Chesire, Amy

AU - Wodarski, Mary

AU - Hickey, Charlyne

AU - Panegyres, Peter

AU - Lee, Joseph

AU - Andrew, Steve

AU - Perlmutter, Joel

AU - Barton, Stacey

AU - Schmidt, Amy

AU - Miedzybrodzka, Zosia

AU - Rae, Daniela

AU - D'Alessandro, Mariella

AU - Craufurd, David

AU - Bek, Judith

AU - Howard, Elizabeth

AU - Mazzoni, Pietro

AU - Marder, Karen

AU - Wasserman, Paula

AU - Kumar, Rajeev

AU - Erickson, Diane

AU - Wheelock, Vicki

AU - Tempkin, Terry

AU - Kjer, Lisa

AU - Martin, Wayne

AU - King, Pamela

AU - Wieler, Marguerite

AU - Sran, Satwinder

AU - Suchowersky, Oksana

AU - Ahmed, Anwar

AU - Rao, Stephen

AU - Reece, Christine

AU - Bura, Alex

AU - Mourany, Lyla

AU - Schulz, Juliet

AU - Long, Jeffrey D.

AU - Montross, Kelsey

AU - Bockholt, Jeremy

AU - Blanchard, Steve

AU - Evans, Ken

AU - Matson, Wayne

AU - Peterson, Asa

AU - Mills, James A.

AU - Vonsattel, Jean Paul

AU - Moskowitz, Carol

AU - Vik, Stacie

AU - Harrington, Deborah

AU - Castillo, Gabriel

AU - Morison, Jessica

AU - Reed, Jason

AU - Diaz, Michael

AU - Dobbins, Ian

AU - Hershey, Tamara

AU - Foster, Erin

AU - Moore, Deborah

AU - Westervelt, Holly

AU - Davis, Jennifer

AU - Tremont, Geoff

AU - David, J.

AU - Gehl, Carissa

AU - Matheson, Kirsty

AU - Siedlecki, Karen

AU - Walsem, Marleen Van

AU - Elias, Greg

AU - Gover, Mary

AU - Bernier, Rachel

AU - Carlozzi, Noelle

AU - Duff, Kevin

AU - Nellie Georgiou-Karistianis, Georgiou-Karistianis

AU - Papp, Kate

AU - Willia, Janet

AU - Clark, Lee Anna

AU - Downing, Nancy

AU - Harreld, Michelle

AU - Ready, Rebecca

AU - Vaccarino, Anthony

AU - Farias, Sarah

AU - MacDonald, Marcy

AU - Gusella, Jim

AU - Myers, Rick

AU - Ross, Christopher

AU - Jones, Kathy

AU - Marietta, Jacquie

AU - Harris, Greg

AU - Kim, Eun Young

AU - Ennis, Greg

AU - Ashburner, John

AU - Potkin, Steve

AU - Toga, Arthur

AU - Axelson, Eric

AU - Reading, Sarah

AU - Beg, Mirza Faisal

AU - Helmer, Karl

AU - Lim, Kelvin

AU - Lowe, Mark

AU - Mori, Sasumu

AU - Song, Allen

AU - Turner, Jessica

AU - Beall, Erik

AU - Koenig, Katherine

AU - Phillips, Michael

AU - Zimbelman, Jan

AU - Fiedorowicz, Jess

AU - Robinson, Robert

AU - Smith, Megan

AU - Beglinger, Leigh

AU - Williams, Janet

AU - Liu, Dawei

AU - Moser, David

AU - Rowe, Kelly

AU - Anderson, Karen

AU - Groves, Mark

AU - Rickards, Hugh

AU - Van Duijn, Eric

AU - Kim, Ji In

AU - Zhang, Ying

AU - Lu, Wenjing

AU - Stout, Craig

AU - Lourens, Spencer

AU - Nance, Martha

AU - Thompson, Sean

AU - Erwin, Cheryl

AU - Hughes, Lisa

AU - Smith, Jim

AU - Zschiegner, Roland

AU - Wyse, Ryan

AU - Wade, Owen

AU - Weston, Derek

AU - Werling-Witkoske, Chris

AU - Anderson, Karla

AU - Lichty, Brittany

AU - Davis, Leann

AU - Danzer, Phil

PY - 2014/3/1

Y1 - 2014/3/1

N2 - Huntington disease (HD) is a neurodegenerative disorder that involves preferential atrophy in the striatal complex and related subcortical nuclei. In this article, which is based on a dataset extracted from the PREDICT-HD study, we use statistical shape analysis with deformation markers obtained through "Large Deformation Diffeomorphic Metric Mapping" of cortical surfaces to highlight specific atrophy patterns in the caudate, putamen, and globus pallidus, at different prodromal stages of the disease. On the basis of the relation to cortico-basal ganglia circuitry, we propose that statistical shape analysis, along with other structural and functional imaging studies, may help expand our understanding of the brain circuitry affected and other aspects of the neurobiology of HD, and also guide the most effective strategies for intervention.

AB - Huntington disease (HD) is a neurodegenerative disorder that involves preferential atrophy in the striatal complex and related subcortical nuclei. In this article, which is based on a dataset extracted from the PREDICT-HD study, we use statistical shape analysis with deformation markers obtained through "Large Deformation Diffeomorphic Metric Mapping" of cortical surfaces to highlight specific atrophy patterns in the caudate, putamen, and globus pallidus, at different prodromal stages of the disease. On the basis of the relation to cortico-basal ganglia circuitry, we propose that statistical shape analysis, along with other structural and functional imaging studies, may help expand our understanding of the brain circuitry affected and other aspects of the neurobiology of HD, and also guide the most effective strategies for intervention.

KW - Diffeomorphic mapping

KW - Pallidus atrophy

KW - Striatal atrophy

KW - Surface registration

KW - Surface-based morphometry

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UR - http://www.scopus.com/inward/citedby.url?scp=84893816723&partnerID=8YFLogxK

U2 - 10.1002/hbm.22214

DO - 10.1002/hbm.22214

M3 - Article

C2 - 23281100

AN - SCOPUS:84893816723

SN - 1065-9471

VL - 35

SP - 792

EP - 809

JO - Human Brain Mapping

JF - Human Brain Mapping

IS - 3

ER -

Regionally selective atrophy of subcortical structures in prodromal HD as revealed by statistical shape analysis

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