Regulation of DNA glycosylases and their role in limiting disease

Harini Sampath; Amanda K. McCullough; R. Stephen Lloyd

doi:10.3109/10715762.2012.655730

Regulation of DNA glycosylases and their role in limiting disease

Harini Sampath, Amanda K. McCullough, R. Stephen Lloyd

Research output: Contribution to journal › Review article › peer-review

38 Scopus citations

Abstract

This review will present a current understanding of mechanisms for the initiation of base excision repair (BER) of oxidatively-induced DNA damage and the biological consequences of deficiencies in these enzymes in mouse model systems and human populations.

Original language	English (US)
Pages (from-to)	460-478
Number of pages	19
Journal	Free Radical Research
Volume	46
Issue number	4
DOIs	https://doi.org/10.3109/10715762.2012.655730
State	Published - Apr 2012

Keywords

Glycosylase-deficient mice
MUTYH
Metabolic disease
NEIL1,2,3
NTH1
OGG1

ASJC Scopus subject areas

Biochemistry

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10.3109/10715762.2012.655730

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title = "Regulation of DNA glycosylases and their role in limiting disease",

abstract = "This review will present a current understanding of mechanisms for the initiation of base excision repair (BER) of oxidatively-induced DNA damage and the biological consequences of deficiencies in these enzymes in mouse model systems and human populations.",

keywords = "Glycosylase-deficient mice, MUTYH, Metabolic disease, NEIL1,2,3, NTH1, OGG1",

author = "Harini Sampath and McCullough, {Amanda K.} and {Stephen Lloyd}, R.",

year = "2012",

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AU - McCullough, Amanda K.

AU - Stephen Lloyd, R.

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N2 - This review will present a current understanding of mechanisms for the initiation of base excision repair (BER) of oxidatively-induced DNA damage and the biological consequences of deficiencies in these enzymes in mouse model systems and human populations.

AB - This review will present a current understanding of mechanisms for the initiation of base excision repair (BER) of oxidatively-induced DNA damage and the biological consequences of deficiencies in these enzymes in mouse model systems and human populations.

KW - Glycosylase-deficient mice

KW - MUTYH

KW - Metabolic disease

KW - NEIL1,2,3

KW - NTH1

KW - OGG1

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Regulation of DNA glycosylases and their role in limiting disease

Abstract

Keywords

ASJC Scopus subject areas

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