TY - JOUR
T1 - Regulation of gene expression in human cancers by TRIM24
AU - Appikonda, Srikanth
AU - Thakkar, Kaushik N.
AU - Barton, Michelle Craig
N1 - Funding Information:
We thank the members of our laboratory for helpful discussions. This work was supported in part by a Cancer Prevention and Research Institute of Texas Grant RP110471 and an UT MD Anderson Cancer Center for Cancer Epigenetics award to MCB. Our studies relied in part on the UT MD Anderson Cancer Center Science Park NGS Core, supported by CPRIT Core Facility Support Grant RP120348 , and the UT MD Anderson Cancer Center NCI Support Grant CA016672 .
Publisher Copyright:
© 2016 Elsevier Ltd
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Tripartite Motif-containing protein 24 (TRIM24) functions as an E3 ligase targeting p53 for ubiquitination, a histone ‘reader’ that interacts with a specific signature of histone post-translational modifications and a co-regulator of nuclear receptor-regulated transcription. Although mouse models of Trim24 depletion suggest that TRIM24 may be a liver-specific tumor suppressor, several studies show that human TRIM24 is an oncogene when aberrantly over expressed. This review focuses on the mechanisms of TRIM24 functions in oncogenesis and metabolic reprogramming, which underlie recent interest in therapeutic targeting of aberrant TRIM24 in human cancers.
AB - Tripartite Motif-containing protein 24 (TRIM24) functions as an E3 ligase targeting p53 for ubiquitination, a histone ‘reader’ that interacts with a specific signature of histone post-translational modifications and a co-regulator of nuclear receptor-regulated transcription. Although mouse models of Trim24 depletion suggest that TRIM24 may be a liver-specific tumor suppressor, several studies show that human TRIM24 is an oncogene when aberrantly over expressed. This review focuses on the mechanisms of TRIM24 functions in oncogenesis and metabolic reprogramming, which underlie recent interest in therapeutic targeting of aberrant TRIM24 in human cancers.
UR - http://www.scopus.com/inward/record.url?scp=84992409529&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84992409529&partnerID=8YFLogxK
U2 - 10.1016/j.ddtec.2016.05.001
DO - 10.1016/j.ddtec.2016.05.001
M3 - Review article
C2 - 27769359
AN - SCOPUS:84992409529
SN - 1740-6749
VL - 19
SP - 57
EP - 63
JO - Drug Discovery Today: Technologies
JF - Drug Discovery Today: Technologies
ER -