Regulation of Glutamate, GABA and Dopamine Transporter Uptake, Surface Mobility and Expression

Renae M. Ryan, Susan L. Ingram, Annalisa Scimemi

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


Neurotransmitter transporters limit spillover between synapses and maintain the extracellular neurotransmitter concentration at low yet physiologically meaningful levels. They also exert a key role in providing precursors for neurotransmitter biosynthesis. In many cases, neurons and astrocytes contain a large intracellular pool of transporters that can be redistributed and stabilized in the plasma membrane following activation of different signaling pathways. This means that the uptake capacity of the brain neuropil for different neurotransmitters can be dynamically regulated over the course of minutes, as an indirect consequence of changes in neuronal activity, blood flow, cell-to-cell interactions, etc. Here we discuss recent advances in the mechanisms that control the cell membrane trafficking and biophysical properties of transporters for the excitatory, inhibitory and modulatory neurotransmitters glutamate, GABA, and dopamine.

Original languageEnglish (US)
Article number670346
JournalFrontiers in Cellular Neuroscience
StatePublished - Apr 13 2021


  • GABA
  • dopamine
  • glutamate
  • surface mobility
  • transporter
  • uptake

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience


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