Regulation of Respiratory Genes by ResD-ResE Signal Transduction System in Bacillus subtilis

Hao Geng, Peter Zuber, Michiko M. Nakano

Research output: Chapter in Book/Report/Conference proceedingChapter

17 Scopus citations


Successful respiration in Bacillus subtilis using oxygen or nitrate as the terminal electron acceptor requires the ResD-ResE signal transduction system. Although transcription of ResDE-controlled genes is induced at the stationary phase of aerobic growth, it is induced to a higher extent upon oxygen limitation. Furthermore, maximal transcriptional activation requires not only oxygen limitation, but also nitric oxide (NO). Oxygen limitation likely results in conversion of the ResE sensor kinase activity from a phosphatase-dominant to a kinase-dominant mode. In addition, low oxygen levels promote the production and maintenance of NO during nitrate respiration, which leads to elimination of the repression exerted by the NO-sensitive transcriptional regulator NsrR. ResD, after undergoing ResE-mediated phosphorylation, interacts with the C-terminal domain of the α subunit of RNA polymerase to activate transcription initiation at ResDE-controlled promoters.

Original languageEnglish (US)
Title of host publicationTwo Component Signaling Systems, Part A
PublisherAcademic Press Inc.
Number of pages17
StatePublished - 2007
Externally publishedYes

Publication series

NameMethods in Enzymology
ISSN (Print)0076-6879

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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