Regulation of somatic growth by the p160 coactivator p/CIP

Zhiyong Wang, David W. Rose, Ola Hermanson, Forrest Liu, Thomas Herman, Wei Wu, Daniel Szeto, Anatoli Gleiberman, Anna Krones, Katherine Pratt, Ron Rosenfeld, Christopher K. Glass, Michael G. Rosenfeld

Research output: Contribution to journalArticlepeer-review

173 Scopus citations


A family of p160 coactivators was initially identified based on ligand-dependent interactions with nuclear receptors and thought to function, in part, by recruiting CREB-binding protein/p300 to several classes of transcription factors. One of the p160 factors, p/CIP/AIB1, often amplified and overexpressed in breast cancer, also exhibits particularly strong interaction with CREB-binding protein/p300. In this manuscript, we report that p/CIP, which exhibits regulated transfer from cytoplasm to nucleus, is required for normal somatic growth from embryonic day 13.5 through maturity. Our data suggest that a short stature pheno-type of p/CIP gene-deleted mice reflect both altered regulation of insulin-like growth factor-1 (IGF-1) gene expression in specific tissues and a cell-autonomous defect of response to IGF-1, including ineffective transcriptional activities by several classes of regulated transcription factors under specific conditions. The actions of p/CIP are therefore required for full expression of a subset of genes critical for regulating physiological patterns of somatic growth in mammals.

Original languageEnglish (US)
Pages (from-to)13549-13554
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number25
StatePublished - Dec 5 2000
Externally publishedYes

ASJC Scopus subject areas

  • General


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