Regulation of thermogenesis by the central melanocortin system

Wei Fan; Adriana Voss-Andreae; Wei Hua Cao; Shaun F. Morrison

doi:10.1016/j.peptides.2004.11.033

Regulation of thermogenesis by the central melanocortin system

Wei Fan, Adriana Voss-Andreae, Wei Hua Cao, Shaun F. Morrison

Research output: Contribution to journal › Review article › peer-review

60 Scopus citations

Abstract

Adaptive thermogenesis represents one of the important homeostatic mechanisms by which the body maintains appropriate levels of stored energy and its core temperature. Dysregulation of adaptive thermogenesis promotes obesity. The central melanocortin system, in particular the melanocortin 4 receptor (MC4R) signaling pathway, influences the regulation of every aspect of energy balance, including thermogenesis, and plays a critical role in energy homeostasis in both rodent and man. This review will outline our current understanding of adaptive thermogenesis, focusing on the role of the central melanocortin pathway in the regulation of thermogenesis.

Original language	English (US)
Pages (from-to)	1800-1813
Number of pages	14
Journal	Peptides
Volume	26
Issue number	10
DOIs	https://doi.org/10.1016/j.peptides.2004.11.033
State	Published - Oct 2005
Externally published	Yes

Keywords

AGRP
BAT
Central circuits
Diet-induced thermogenesis
Melanocortin
Obesity
POMC
Pathogenic stimuli
Sympathetic nervous system
Thermogenesis
Thyroid
UCP

ASJC Scopus subject areas

Biochemistry
Physiology
Endocrinology
Cellular and Molecular Neuroscience

Access to Document

10.1016/j.peptides.2004.11.033

Cite this

@article{1e8a2baddb354f858d92f7e12af48ad1,

title = "Regulation of thermogenesis by the central melanocortin system",

abstract = "Adaptive thermogenesis represents one of the important homeostatic mechanisms by which the body maintains appropriate levels of stored energy and its core temperature. Dysregulation of adaptive thermogenesis promotes obesity. The central melanocortin system, in particular the melanocortin 4 receptor (MC4R) signaling pathway, influences the regulation of every aspect of energy balance, including thermogenesis, and plays a critical role in energy homeostasis in both rodent and man. This review will outline our current understanding of adaptive thermogenesis, focusing on the role of the central melanocortin pathway in the regulation of thermogenesis.",

keywords = "AGRP, BAT, Central circuits, Diet-induced thermogenesis, Melanocortin, Obesity, POMC, Pathogenic stimuli, Sympathetic nervous system, Thermogenesis, Thyroid, UCP",

author = "Wei Fan and Adriana Voss-Andreae and Cao, {Wei Hua} and Morrison, {Shaun F.}",

note = "Funding Information: This work is supported by US National Institutes of Health Grants NIDDK 62179 (WF) and NIDDK57838 (SFM).",

year = "2005",

month = oct,

doi = "10.1016/j.peptides.2004.11.033",

language = "English (US)",

volume = "26",

pages = "1800--1813",

journal = "Peptides",

issn = "0196-9781",

publisher = "Elsevier Inc.",

number = "10",

}

TY - JOUR

T1 - Regulation of thermogenesis by the central melanocortin system

AU - Fan, Wei

AU - Voss-Andreae, Adriana

AU - Cao, Wei Hua

AU - Morrison, Shaun F.

N1 - Funding Information: This work is supported by US National Institutes of Health Grants NIDDK 62179 (WF) and NIDDK57838 (SFM).

PY - 2005/10

Y1 - 2005/10

N2 - Adaptive thermogenesis represents one of the important homeostatic mechanisms by which the body maintains appropriate levels of stored energy and its core temperature. Dysregulation of adaptive thermogenesis promotes obesity. The central melanocortin system, in particular the melanocortin 4 receptor (MC4R) signaling pathway, influences the regulation of every aspect of energy balance, including thermogenesis, and plays a critical role in energy homeostasis in both rodent and man. This review will outline our current understanding of adaptive thermogenesis, focusing on the role of the central melanocortin pathway in the regulation of thermogenesis.

AB - Adaptive thermogenesis represents one of the important homeostatic mechanisms by which the body maintains appropriate levels of stored energy and its core temperature. Dysregulation of adaptive thermogenesis promotes obesity. The central melanocortin system, in particular the melanocortin 4 receptor (MC4R) signaling pathway, influences the regulation of every aspect of energy balance, including thermogenesis, and plays a critical role in energy homeostasis in both rodent and man. This review will outline our current understanding of adaptive thermogenesis, focusing on the role of the central melanocortin pathway in the regulation of thermogenesis.

KW - AGRP

KW - BAT

KW - Central circuits

KW - Diet-induced thermogenesis

KW - Melanocortin

KW - Obesity

KW - POMC

KW - Pathogenic stimuli

KW - Sympathetic nervous system

KW - Thermogenesis

KW - Thyroid

KW - UCP

UR - http://www.scopus.com/inward/record.url?scp=25144438002&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=25144438002&partnerID=8YFLogxK

U2 - 10.1016/j.peptides.2004.11.033

DO - 10.1016/j.peptides.2004.11.033

M3 - Review article

C2 - 15979759

AN - SCOPUS:25144438002

SN - 0196-9781

VL - 26

SP - 1800

EP - 1813

JO - Peptides

JF - Peptides

IS - 10

ER -

Regulation of thermogenesis by the central melanocortin system

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this