Regulatory mechanisms of AMPA receptors in synaptic plasticity

Victor A. Derkach, Michael C. Oh, Eric S. Guire, Thomas R. Soderling

Research output: Contribution to journalReview articlepeer-review

554 Scopus citations


Activity-dependent changes in the strength of excitatory synapses are a cellular mechanism for the plasticity of neuronal networks that is widely recognized to underlie cognitive functions such as learning and memory. AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid)-type glutamate receptors (AMPARs) are the main transducers of rapid excitatory transmission in the mammalian CNS, and recent discoveries indicate that the mechanisms which regulate AMPARs are more complex than previously thought. This review focuses on recent evidence that alterations to AMPAR functional properties are coupled to their trafficking, cytoskeletal dynamics and local protein synthesis. These relationships offer new insights into the regulation of AMPARs and synaptic strength by cellular signalling.

Original languageEnglish (US)
Pages (from-to)101-113
Number of pages13
JournalNature Reviews Neuroscience
Issue number2
StatePublished - Feb 2007
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)


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