Relationship between smoking and the single breath nitrogen washout

A. S. Buist, J. M. Nagy

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


In 1974, a collaborative study was carried out in three North American cities; Portland, Oregon, Montreal, Quebec, and Winnipeg, Manitoba. The objectives of this study were to determine the distribution of closure volume (CV) by age, sex and smoking habits in a defined population and to analyze the relationships between CV and smoking in each sex, having standardized for age. We found that nonsmokers in different cities appear to be very similar in terms of closing volume/vital capacity (CV/VC), closing capacity/total lung capacity (CC/TLC) and the slope of alveolar plateau ΔN2/L and that smokers are different from nonsmokers in terms of these variables. We also found that age has a far greater effect on the variables tested than smoking. From this we conclude that some factor or factors interact with smoking in the development of irreversible airway obstruction.

Original languageEnglish (US)
Pages (from-to)108-116
Number of pages9
JournalScandinavian Journal of Respiratory Diseases
StatePublished - 1976

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Relationship between smoking and the single breath nitrogen washout'. Together they form a unique fingerprint.

Cite this