TY - JOUR
T1 - Remodelling of neuromuscular systems during insect metamorphosis
AU - Kent, Karla S.
AU - Consoulas, Christos
AU - Duncan, Karen
AU - Johnston, Rebecca M.
AU - Luedeman, Rene
AU - Levine, Richard B.
N1 - Funding Information:
This work was supported by NIH grants NS24822 and NS28495 awarded to RBL and NSF grant IBN 9209497 awarded to KSK. Dr. Consoulas was supported by a fellowship from the Fogarty International Center (TWO 4898) and Dr. Johnston was supported by a fellowship from NIH (NS09387). The authors wish to thank Dr. Maureen Mulcahy for essential technical help during the initial stages of this work.
PY - 1995/12
Y1 - 1995/12
N2 - During metamorphosis in the hawkmoth, Manduca sexta, the larval thoracic legs are replaced by a new set of adult legs that include new sensory neurons and muscles, and participate in new patterns of locomotor activity. Larval leg motoneurons persist to innervate the new adult leg muscles, but undergo striking changes in dendritic morphology that are regulated by the insect steroid, 20-hydroxyecdysone. In the periphery, the motor terminals regress as larval muscles degenerate, and expand as new adult muscles form from myoblasts. Evidence obtained both in vivo and in vitro suggests that the proliferation of myoblasts during metamorphosis is dependent upon innervation.
AB - During metamorphosis in the hawkmoth, Manduca sexta, the larval thoracic legs are replaced by a new set of adult legs that include new sensory neurons and muscles, and participate in new patterns of locomotor activity. Larval leg motoneurons persist to innervate the new adult leg muscles, but undergo striking changes in dendritic morphology that are regulated by the insect steroid, 20-hydroxyecdysone. In the periphery, the motor terminals regress as larval muscles degenerate, and expand as new adult muscles form from myoblasts. Evidence obtained both in vivo and in vitro suggests that the proliferation of myoblasts during metamorphosis is dependent upon innervation.
UR - http://www.scopus.com/inward/record.url?scp=77957217073&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77957217073&partnerID=8YFLogxK
U2 - 10.1093/icb/35.6.578
DO - 10.1093/icb/35.6.578
M3 - Article
AN - SCOPUS:77957217073
SN - 1540-7063
VL - 35
SP - 578
EP - 584
JO - Integrative and Comparative Biology
JF - Integrative and Comparative Biology
IS - 6
ER -