Renal expression of IGF I in hypersomatotropic states

S. B. Miller; P. Rotwein; J. D. Bortz; P. J. Bechtel; V. A. Hansen; S. A. Rogers; M. R. Hammerman

doi:10.1152/ajprenal.1990.259.2.f251

Renal expression of IGF I in hypersomatotropic states

S. B. Miller, P. Rotwein, J. D. Bortz, P. J. Bechtel, V. A. Hansen, S. A. Rogers, M. R. Hammerman

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

We examined insulin-like growth factor I (IGF I) gene expression in kidney in two models of hypersomatotropism, rats implanted with GH₃ pituitary tumors, and rats administered exogenous growth hormone (GH). Both GH₃ tumor-bearing rats and rats administered GH gained weight more rapidly than control animals, and had kidneys that were larger than those of controls. Tumor-bearing rats had increased levels of circulating IGF I. Glomeruli from tumor-implanted rats were sclerotic. Immunostainable IGF I was increased in medullary collecting ducts from tumor-bearing and GH-injected rats compared with kidneys from control animals. Levels of IGF I mRNA in kidneys of rats implanted with GH₃ tumors and GH-injected rats were elevated compared with levels in kidneys from controls. Our findings demonstrate enhanced renal IGF I gene expression in hypersomatotropism. Stimulation of renal IGF I synthesis by GH could be causative of changes in renal function and renal size that occur in states of GH excess such as acromegaly.

Original language	English (US)
Pages (from-to)	F251-F257
Journal	American Journal of Physiology - Renal Fluid and Electrolyte Physiology
Volume	259
Issue number	2 28-2
DOIs	https://doi.org/10.1152/ajprenal.1990.259.2.f251
State	Published - 1990
Externally published	Yes

Keywords

acromegaly
growth hormone
renal hypertrophy

ASJC Scopus subject areas

Physiology

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10.1152/ajprenal.1990.259.2.f251

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title = "Renal expression of IGF I in hypersomatotropic states",

abstract = "We examined insulin-like growth factor I (IGF I) gene expression in kidney in two models of hypersomatotropism, rats implanted with GH3 pituitary tumors, and rats administered exogenous growth hormone (GH). Both GH3 tumor-bearing rats and rats administered GH gained weight more rapidly than control animals, and had kidneys that were larger than those of controls. Tumor-bearing rats had increased levels of circulating IGF I. Glomeruli from tumor-implanted rats were sclerotic. Immunostainable IGF I was increased in medullary collecting ducts from tumor-bearing and GH-injected rats compared with kidneys from control animals. Levels of IGF I mRNA in kidneys of rats implanted with GH3 tumors and GH-injected rats were elevated compared with levels in kidneys from controls. Our findings demonstrate enhanced renal IGF I gene expression in hypersomatotropism. Stimulation of renal IGF I synthesis by GH could be causative of changes in renal function and renal size that occur in states of GH excess such as acromegaly.",

keywords = "acromegaly, growth hormone, renal hypertrophy",

author = "Miller, {S. B.} and P. Rotwein and Bortz, {J. D.} and Bechtel, {P. J.} and Hansen, {V. A.} and Rogers, {S. A.} and Hammerman, {M. R.}",

year = "1990",

doi = "10.1152/ajprenal.1990.259.2.f251",

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AU - Miller, S. B.

AU - Rotwein, P.

AU - Bortz, J. D.

AU - Bechtel, P. J.

AU - Hansen, V. A.

AU - Rogers, S. A.

AU - Hammerman, M. R.

PY - 1990

Y1 - 1990

N2 - We examined insulin-like growth factor I (IGF I) gene expression in kidney in two models of hypersomatotropism, rats implanted with GH3 pituitary tumors, and rats administered exogenous growth hormone (GH). Both GH3 tumor-bearing rats and rats administered GH gained weight more rapidly than control animals, and had kidneys that were larger than those of controls. Tumor-bearing rats had increased levels of circulating IGF I. Glomeruli from tumor-implanted rats were sclerotic. Immunostainable IGF I was increased in medullary collecting ducts from tumor-bearing and GH-injected rats compared with kidneys from control animals. Levels of IGF I mRNA in kidneys of rats implanted with GH3 tumors and GH-injected rats were elevated compared with levels in kidneys from controls. Our findings demonstrate enhanced renal IGF I gene expression in hypersomatotropism. Stimulation of renal IGF I synthesis by GH could be causative of changes in renal function and renal size that occur in states of GH excess such as acromegaly.

AB - We examined insulin-like growth factor I (IGF I) gene expression in kidney in two models of hypersomatotropism, rats implanted with GH3 pituitary tumors, and rats administered exogenous growth hormone (GH). Both GH3 tumor-bearing rats and rats administered GH gained weight more rapidly than control animals, and had kidneys that were larger than those of controls. Tumor-bearing rats had increased levels of circulating IGF I. Glomeruli from tumor-implanted rats were sclerotic. Immunostainable IGF I was increased in medullary collecting ducts from tumor-bearing and GH-injected rats compared with kidneys from control animals. Levels of IGF I mRNA in kidneys of rats implanted with GH3 tumors and GH-injected rats were elevated compared with levels in kidneys from controls. Our findings demonstrate enhanced renal IGF I gene expression in hypersomatotropism. Stimulation of renal IGF I synthesis by GH could be causative of changes in renal function and renal size that occur in states of GH excess such as acromegaly.

KW - acromegaly

KW - growth hormone

KW - renal hypertrophy

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JO - American Journal of Physiology - Renal Fluid and Electrolyte Physiology

JF - American Journal of Physiology - Renal Fluid and Electrolyte Physiology

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ER -

Renal expression of IGF I in hypersomatotropic states

Abstract

Keywords

ASJC Scopus subject areas

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