TY - JOUR
T1 - Research advances in cochlear pericytes and hearing loss
AU - Shi, Xiaorui
N1 - Publisher Copyright:
© 2023 The Author
PY - 2023/10
Y1 - 2023/10
N2 - Pericytes are specialized mural cells surrounding endothelial cells in microvascular beds. They play a role in vascular development, blood flow regulation, maintenance of blood-tissue barrier integrity, and control of angiogenesis, tissue fibrosis, and wound healing. In recent decades, understanding of the critical role played by pericytes in retina, brain, lung, and kidney has seen significant progress. The cochlea contains a large population of pericytes. However, the role of cochlear pericytes in auditory pathophysiology is, by contrast, largely unknown. The present review discusses recent progress in identifying cochlear pericytes, mapping their distribution, and defining their role in regulating blood flow, controlling the blood-labyrinth barrier (BLB) and angiogenesis, and involvement in different types of hearing loss.
AB - Pericytes are specialized mural cells surrounding endothelial cells in microvascular beds. They play a role in vascular development, blood flow regulation, maintenance of blood-tissue barrier integrity, and control of angiogenesis, tissue fibrosis, and wound healing. In recent decades, understanding of the critical role played by pericytes in retina, brain, lung, and kidney has seen significant progress. The cochlea contains a large population of pericytes. However, the role of cochlear pericytes in auditory pathophysiology is, by contrast, largely unknown. The present review discusses recent progress in identifying cochlear pericytes, mapping their distribution, and defining their role in regulating blood flow, controlling the blood-labyrinth barrier (BLB) and angiogenesis, and involvement in different types of hearing loss.
KW - Angiogenesis
KW - Blood flow regulation
KW - Endothelial barrier
KW - Hearing loss
KW - Pericyte
UR - http://www.scopus.com/inward/record.url?scp=85169003513&partnerID=8YFLogxK
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U2 - 10.1016/j.heares.2023.108877
DO - 10.1016/j.heares.2023.108877
M3 - Review article
C2 - 37651921
AN - SCOPUS:85169003513
SN - 0378-5955
VL - 438
JO - Hearing Research
JF - Hearing Research
M1 - 108877
ER -