TY - JOUR
T1 - Resting state functional connectivity of the nucleus accumbens in youth with a family history of alcoholism
AU - Cservenka, Anita
AU - Casimo, Kaitlyn
AU - Fair, Damien
AU - Nagel, Bonnie J.
N1 - Funding Information:
Grant support for the authors of this study was provided by R01 AA017664 ( Nagel ), U01 AA021691 ( Nagel ), a pilot grant to Nagel from the Portland Alcohol Research Center ( P60 AA010760 (Crabbe) ), R01 MH096773 ( Fair ), R00 MH091238 ( Fair ), and the Oregon Clinical & Translational Research Institute (Fair) .
PY - 2014/3/30
Y1 - 2014/3/30
N2 - Adolescents with a family history of alcoholism (FHP) are at heightened risk for developing alcohol use disorders (AUDs). The nucleus accumbens (NAcc), a key brain region for reward processing, is implicated in the development of AUDs. Thus, functional connectivity of the NAcc may be an important marker of risk in FHP youth. Resting state functional magnetic resonance imaging (rs-fcMRI) was used to examine the intrinsic connectivity of the NAcc in 47 FHP and 50 family history negative (FHN) youth, ages 10-16 years old. FHP and FHN adolescents showed significant group differences in resting state synchrony between the left NAcc and bilateral inferior frontal gyri and the left postcentral gyrus (PG). Additionally, FHP youth differed from FHN youth in right NAcc functional connectivity with the left orbitofrontal cortex (OFC), left superior temporal gyrus, right cerebellum, left PG, and right occipital cortex. These results indicate that FHP youth have less segregation between the NAcc and executive functioning brain regions, and less integration with reward-related brain areas, such as the OFC. The findings of the current study highlight that premorbid atypical connectivity of appetitive systems, in the absence of heavy alcohol use, may be a risk marker in FHP adolescents.
AB - Adolescents with a family history of alcoholism (FHP) are at heightened risk for developing alcohol use disorders (AUDs). The nucleus accumbens (NAcc), a key brain region for reward processing, is implicated in the development of AUDs. Thus, functional connectivity of the NAcc may be an important marker of risk in FHP youth. Resting state functional magnetic resonance imaging (rs-fcMRI) was used to examine the intrinsic connectivity of the NAcc in 47 FHP and 50 family history negative (FHN) youth, ages 10-16 years old. FHP and FHN adolescents showed significant group differences in resting state synchrony between the left NAcc and bilateral inferior frontal gyri and the left postcentral gyrus (PG). Additionally, FHP youth differed from FHN youth in right NAcc functional connectivity with the left orbitofrontal cortex (OFC), left superior temporal gyrus, right cerebellum, left PG, and right occipital cortex. These results indicate that FHP youth have less segregation between the NAcc and executive functioning brain regions, and less integration with reward-related brain areas, such as the OFC. The findings of the current study highlight that premorbid atypical connectivity of appetitive systems, in the absence of heavy alcohol use, may be a risk marker in FHP adolescents.
KW - Adolescence
KW - Alcohol
KW - Familial
KW - Risk
KW - Ventral striatum
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U2 - 10.1016/j.pscychresns.2013.12.004
DO - 10.1016/j.pscychresns.2013.12.004
M3 - Article
C2 - 24440571
AN - SCOPUS:84894350825
SN - 0925-4927
VL - 221
SP - 210
EP - 219
JO - Psychiatry Research - Neuroimaging
JF - Psychiatry Research - Neuroimaging
IS - 3
ER -