Retinoid therapy is associated with excess granulation tissue responses

Janis P. Campbell, Roy C. Grekin, Charles N. Ellis, Stella S. Matsuda-John, Neil A. Swanson, John J. Voorhees

Research output: Contribution to journalArticlepeer-review

78 Scopus citations


In our clinical trials of isotretinoin therapy for cystic acne and etretinate treatment of psoriasis, eight patients had growth of excessive granulation tissue. The granulation tissue was found in resolving acne lesions in one patient taking isotretinoin. Among the psoriatic patients taking etretinate, the granulation tissue usually was seen adjacent to nail plates. In two patients, the side effect caused them to stop retinoid therapy. The tissue response did not appear to be related to the daily or cumulative retinoid dose.

Original languageEnglish (US)
Pages (from-to)708-713
Number of pages6
JournalJournal of the American Academy of Dermatology
Issue number5
StatePublished - 1983
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology


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