TY - JOUR
T1 - Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats
AU - Moghaddam, Bita
AU - Adams, Barbara W.
PY - 1998/8/28
Y1 - 1998/8/28
N2 - Glutamatergic abnormalities have been associated with several psychiatric disorders, including schizophrenia and addiction. Group II metabotropic glutamate receptors were targeted to normalize glutamatergic disruptions associated with an animal model of schizophrenia, the phencyclidine model. An agonist of this group of receptors, at a dose that was without effects on spontaneous activity and corticolimbic dopamine neurotransmission, attenuated the disruptive effects of phencyclidine on working memory, stereotypy, locomotion, and cortical glutamate efflux. This behavioral reversal occurred in spite of sustained dopamine hyperactivity. Thus, targeting this group of receptors may present a nondopaminergic therapeutic strategy for treatment of psychiatric disorders.
AB - Glutamatergic abnormalities have been associated with several psychiatric disorders, including schizophrenia and addiction. Group II metabotropic glutamate receptors were targeted to normalize glutamatergic disruptions associated with an animal model of schizophrenia, the phencyclidine model. An agonist of this group of receptors, at a dose that was without effects on spontaneous activity and corticolimbic dopamine neurotransmission, attenuated the disruptive effects of phencyclidine on working memory, stereotypy, locomotion, and cortical glutamate efflux. This behavioral reversal occurred in spite of sustained dopamine hyperactivity. Thus, targeting this group of receptors may present a nondopaminergic therapeutic strategy for treatment of psychiatric disorders.
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U2 - 10.1126/science.281.5381.1349
DO - 10.1126/science.281.5381.1349
M3 - Article
C2 - 9721099
AN - SCOPUS:0032575715
SN - 0036-8075
VL - 281
SP - 1349
EP - 1352
JO - Science
JF - Science
IS - 5381
ER -