Reversible gastric restriction implant: Safety and efficacy in a canine model

Xiaomei Guo, Hai Zheng, Samer G. Mattar, Xiao Lu, George Sandusky, Jose A. Navia, Ghassan Kassab

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Background: Gastric restrictive procedures are considered effective weight loss treatment for severe obesity. The aim of the study was to evaluate the efficacy and safety of a reversible implant that renders a partial restriction of stomach in a canine model. Methods: The device was comprised of two longitudinal parallel non-compressive plates with two C-rings to create a small gastric pouch that opposed gastric distension. Three groups of non-obese mongrel dogs were included: group I (n∈=∈6) underwent surgical implant for 6 weeks, group II (n∈=∈6) underwent surgical implant for 6 weeks, followed by surgical removal of the implant and additional monitoring for 5 weeks, and group III (n∈=∈5) served as sham-operated controls for groups I and II. Food intake and body weight were monitored, and the stomachs were examined histologically postmortem. Results: The average food intake was significantly decreased by 38.2% in group I as compared to group III throughout the 6 weeks of surgical implant (P∈<∈0.05). The implanted dogs showed a progressive weight loss as compared to sham, which reached 21% by the end of 6 weeks. In group II, after 5 weeks of implant removal, the body weights recovered to approximately 96% of baseline. Histological evidence of the implant site at the gastric walls revealed no significant structural changes, tissue ischemia, hemorrhage, or necrosis. Conclusion: Our results validate the feasibility of a reversible gastric restriction implant in a non-obese canine model, with the potential for achieving significant weight loss within 6 weeks and with no injury to the gastric wall.

Original languageEnglish (US)
Pages (from-to)1444-1450
Number of pages7
JournalObesity Surgery
Issue number9
StatePublished - Sep 2011
Externally publishedYes


  • Body weight
  • Food intake
  • Implant
  • Obesity
  • Restrictive procedure

ASJC Scopus subject areas

  • Surgery
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics


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