TY - CHAP
T1 - Ricin and Shiga toxins
T2 - Effects on host cell Signal transduction
AU - Jandhyala, Dakshina M.
AU - Thorpe, Cheleste M.
AU - Magun, Bruce
PY - 2012
Y1 - 2012
N2 - Shiga toxins and ricin are potent inhibitors of protein synthesis. In addition to causing inhibition of protein synthesis, these toxins activate proinflammatory signaling cascades that may contribute to the severe diseases associated with toxin exposure. Treatment of cells with Shiga toxins and ricin have been shown to activate a number of signaling pathways including those associated with the ribotoxic stress response, Nuclear factor kappa B activation, inflammasome activation, the unfolded protein response, mTOR signaling, hemostasis, and retrograde trafficking. In this chapter, we review our current understanding of these signaling pathways as they pertain to intoxication by Shiga toxins and ricin.
AB - Shiga toxins and ricin are potent inhibitors of protein synthesis. In addition to causing inhibition of protein synthesis, these toxins activate proinflammatory signaling cascades that may contribute to the severe diseases associated with toxin exposure. Treatment of cells with Shiga toxins and ricin have been shown to activate a number of signaling pathways including those associated with the ribotoxic stress response, Nuclear factor kappa B activation, inflammasome activation, the unfolded protein response, mTOR signaling, hemostasis, and retrograde trafficking. In this chapter, we review our current understanding of these signaling pathways as they pertain to intoxication by Shiga toxins and ricin.
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U2 - 10.1007/82_2011_181
DO - 10.1007/82_2011_181
M3 - Chapter
C2 - 22057792
AN - SCOPUS:84857866006
SN - 9783642274695
T3 - Current Topics in Microbiology and Immunology
SP - 41
EP - 65
BT - Ricin and Shiga Toxins
A2 - Mantis, Nicholas
A2 - Mantis, Nicholas
ER -