Original language | English (US) |
---|---|
Article number | 113704 |
Journal | Food and Chemical Toxicology |
Volume | 176 |
DOIs | |
State | Published - Jun 2023 |
ASJC Scopus subject areas
- Food Science
- Toxicology
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In: Food and Chemical Toxicology, Vol. 176, 113704, 06.2023.
Research output: Contribution to journal › Short survey › peer-review
}
TY - JOUR
T1 - RIFM fragrance ingredient safety assessment, 2-acetylthiophene, CAS registry number 88-15-3
AU - Api, A. M.
AU - Belsito, D.
AU - Botelho, D.
AU - Bruze, M.
AU - Burton, G. A.
AU - Cancellieri, M. A.
AU - Chon, H.
AU - Dagli, M. L.
AU - Dekant, W.
AU - Deodhar, C.
AU - Fryer, A. D.
AU - Jones, L.
AU - Joshi, K.
AU - Kumar, M.
AU - Lapczynski, A.
AU - Lavelle, M.
AU - Lee, I.
AU - Liebler, D. C.
AU - Moustakas, H.
AU - Na, M.
AU - Penning, T. M.
AU - Ritacco, G.
AU - Romine, J.
AU - Sadekar, N.
AU - Schultz, T. W.
AU - Selechnik, D.
AU - Siddiqi, F.
AU - Sipes, I. G.
AU - Sullivan, G.
AU - Thakkar, Y.
AU - Tokura, Y.
N1 - Funding Information: Limited skin sensitization data are available for 2-acetylthiophene (Table 1). This material was not found to be reactive with skin proteins in silico; however, based on expert judgment, the parent target is expected to react with skin proteins directly (Roberts et al., 2007; Toxtree v3.1.0; OECD Toolbox v4.2). Acting conservatively due to the limited data, the reported exposure was benchmarked utilizing the reactive DST of 64 μg/cm2 (Safford, 2008; Safford, 2011; Roberts et al., 2015; Safford, 2015b). The current exposure from the 95th percentile concentration is below the DST for reactive materials when evaluated in all QRA categories. Table 2 provides the supported concentrations for 2-acetylthiophene that present no appreciable risk for skin sensitization based on the reactive DST. These levels represent supported concentrations based on the DST approach. However, additional studies may show it could be used at higher levels.
PY - 2023/6
Y1 - 2023/6
UR - http://www.scopus.com/inward/record.url?scp=85150755041&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85150755041&partnerID=8YFLogxK
U2 - 10.1016/j.fct.2023.113704
DO - 10.1016/j.fct.2023.113704
M3 - Short survey
C2 - 36889427
AN - SCOPUS:85150755041
SN - 0278-6915
VL - 176
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
M1 - 113704
ER -