Original language | English (US) |
---|---|
Article number | 113309 |
Journal | Food and Chemical Toxicology |
Volume | 167 |
DOIs | |
State | Published - Sep 2022 |
ASJC Scopus subject areas
- Food Science
- Toxicology
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In: Food and Chemical Toxicology, Vol. 167, 113309, 09.2022.
Research output: Contribution to journal › Short survey › peer-review
}
TY - JOUR
T1 - RIFM fragrance ingredient safety assessment, alcohols, C9-11-iso-, C10-rich, CAS Registry Number 68526-85-2
AU - Api, A. M.
AU - Belsito, D.
AU - Botelho, D.
AU - Bruze, M.
AU - Burton, G. A.
AU - Cancellieri, M. A.
AU - Chon, H.
AU - Dagli, M. L.
AU - Date, M.
AU - Dekant, W.
AU - Deodhar, C.
AU - Fryer, A. D.
AU - Jones, L.
AU - Joshi, K.
AU - Kumar, M.
AU - Lapczynski, A.
AU - Lavelle, M.
AU - Lee, I.
AU - Liebler, D. C.
AU - Moustakas, H.
AU - Na, M.
AU - Penning, T. M.
AU - Ritacco, G.
AU - Romine, J.
AU - Sadekar, N.
AU - Schultz, T. W.
AU - Selechnik, D.
AU - Siddiqi, F.
AU - Sipes, I. G.
AU - Sullivan, G.
AU - Thakkar, Y.
AU - Tokura, Y.
N1 - Funding Information: There are no repeated dose toxicity data on alcohols, C9-11-iso-, C10-rich. Read-across material alcohols, C11–C14-iso-, C13- rich (CAS # 68526-86-3; See Section VI) has sufficient data to support the repeated dose toxicity endpoint. In a GLP and OECD 408-compliant study, groups of 10 Sprague-Dawley rats/sex/dose were administered alcohols, C11-14-iso-, C13-rich via gavage at doses of 0, 100, 300, and 1000 mg/kg/day for 90 days. No mortality occurred throughout the study period. No treatment-related adverse effects were observed in clinical signs, food consumption, ophthalmology, urinalysis. Body weights were significantly decreased in males at high dose. Levels of red blood cells (RBCs), hematocrit (HCT), and hemoglobin (HGB) were significantly decreased in females at high dose. Albumin, total protein, and globulin levels were significantly increased in both sexes at high dose. Chloride levels were significantly decreased in females at mid dose and both sexes at high dose. Urea nitrogen levels were significantly increased in males at high dose. Creatinine and alkaline phosphatase levels were increased in males at high dose. Cholesterol values were increased in females at high dose. Absolute and relative kidney and liver weights were significantly increased in both sexes at mid and high dose (correlated with mild renal tubular degeneration and necrosis, dark red discoloration in kidneys of males, hepatocellular hypertrophy in males and females). Absolute and relative adrenal weights were significantly increased in females at mid and high dose. Absolute and relative heart weights were significantly increased in females at high dose. Absolute pituitary gland weights were increased in females at high dose. Based on organ weight changes and histopathologic correlates at 1000 and 300 mg/kg/day, the NOAEL for this study was considered to be 100 mg/kg/day (ECHA, 2011b).
PY - 2022/9
Y1 - 2022/9
UR - http://www.scopus.com/inward/record.url?scp=85135912097&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85135912097&partnerID=8YFLogxK
U2 - 10.1016/j.fct.2022.113309
DO - 10.1016/j.fct.2022.113309
M3 - Short survey
C2 - 35863480
AN - SCOPUS:85135912097
SN - 0278-6915
VL - 167
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
M1 - 113309
ER -