RIFM FRAGRANCE INGREDIENT SAFETY ASSESSMENT, butanoic acid, 3a,4,5,6,7,7a-hexahydro-4,7-methano-1H-indenyl ester, CAS Registry Number 113889-23-9

A. M. Api; D. Belsito; D. Botelho; M. Bruze; G. A. Burton; J. Buschmann; M. L. Dagli; M. Date; W. Dekant; C. Deodhar; M. Francis; A. D. Fryer; L. Jones; K. Joshi; S. La Cava; A. Lapczynski; D. C. Liebler; D. O'Brien; A. Patel; T. M. Penning; G. Ritacco; J. Romine; N. Sadekar; D. Salvito; T. W. Schultz; I. G. Sipes; G. Sullivan; Y. Thakkar; Y. Tokura; S. Tsang

doi:10.1016/j.fct.2018.06.041

RIFM FRAGRANCE INGREDIENT SAFETY ASSESSMENT, butanoic acid, 3a,4,5,6,7,7a-hexahydro-4,7-methano-1H-indenyl ester, CAS Registry Number 113889-23-9

A. M. Api, D. Belsito, D. Botelho, M. Bruze, G. A. Burton, J. Buschmann, M. L. Dagli, M. Date, W. Dekant, C. Deodhar, M. Francis, A. D. Fryer, L. Jones, K. Joshi, S. La Cava, A. Lapczynski, D. C. Liebler, D. O'Brien, A. Patel, T. M. PenningG. Ritacco, J. Romine, N. Sadekar, D. Salvito, T. W. Schultz, I. G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura, S. Tsang

Pulmonary and Critical Care Medicine

Research output: Contribution to journal › Short survey › peer-review

Original language	English (US)
Pages (from-to)	S84-S93
Journal	Food and Chemical Toxicology
Volume	118
DOIs	https://doi.org/10.1016/j.fct.2018.06.041
State	Published - Sep 2018

ASJC Scopus subject areas

Food Science
Toxicology

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10.1016/j.fct.2018.06.041

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Api, A. M., Belsito, D., Botelho, D., Bruze, M., Burton, G. A., Buschmann, J., Dagli, M. L., Date, M., Dekant, W., Deodhar, C., Francis, M., Fryer, A. D., Jones, L., Joshi, K., La Cava, S., Lapczynski, A., Liebler, D. C., O'Brien, D., Patel, A., ... Tsang, S. (2018). RIFM FRAGRANCE INGREDIENT SAFETY ASSESSMENT, butanoic acid, 3a,4,5,6,7,7a-hexahydro-4,7-methano-1H-indenyl ester, CAS Registry Number 113889-23-9. Food and Chemical Toxicology, 118, S84-S93. https://doi.org/10.1016/j.fct.2018.06.041

Api, AM, Belsito, D, Botelho, D, Bruze, M, Burton, GA, Buschmann, J, Dagli, ML, Date, M, Dekant, W, Deodhar, C, Francis, M, Fryer, AD, Jones, L, Joshi, K, La Cava, S, Lapczynski, A, Liebler, DC, O'Brien, D, Patel, A, Penning, TM, Ritacco, G, Romine, J, Sadekar, N, Salvito, D, Schultz, TW, Sipes, IG, Sullivan, G, Thakkar, Y, Tokura, Y & Tsang, S 2018, 'RIFM FRAGRANCE INGREDIENT SAFETY ASSESSMENT, butanoic acid, 3a,4,5,6,7,7a-hexahydro-4,7-methano-1H-indenyl ester, CAS Registry Number 113889-23-9', Food and Chemical Toxicology, vol. 118, pp. S84-S93. https://doi.org/10.1016/j.fct.2018.06.041

@article{2409e32854394b6694c504db5d9a56dd,

title = "RIFM FRAGRANCE INGREDIENT SAFETY ASSESSMENT, butanoic acid, 3a,4,5,6,7,7a-hexahydro-4,7-methano-1H-indenyl ester, CAS Registry Number 113889-23-9",

author = "Api, {A. M.} and D. Belsito and D. Botelho and M. Bruze and Burton, {G. A.} and J. Buschmann and Dagli, {M. L.} and M. Date and W. Dekant and C. Deodhar and M. Francis and Fryer, {A. D.} and L. Jones and K. Joshi and {La Cava}, S. and A. Lapczynski and Liebler, {D. C.} and D. O'Brien and A. Patel and Penning, {T. M.} and G. Ritacco and J. Romine and N. Sadekar and D. Salvito and Schultz, {T. W.} and Sipes, {I. G.} and G. Sullivan and Y. Thakkar and Y. Tokura and S. Tsang",

note = "Funding Information: There are no developmental or reproductive toxicity data on butanoic acid, 3a,4,5,6,7,7a-hexahydro-4,7-methano-1H-indenyl ester. Read-across material acetoxydihydrodicyclopentadiene (CAS # 54830-99-8; see Section V) has sufficient developmental and reproductive toxicity data to support the developmental and reproductive toxicity endpoints. An OECD 421 oral gavage reproduction and developmental toxicity screening test was conducted in Wistar Han:HsdRccHan:WIST strain rats. Groups of 10 rats/sex/dose were administered via oral gavage with test material acetoxydihydrodicyclopentadiene (mixture of isomers) at doses of 0, 100, 300, or 1000 mg/kg/day in an Arachis oil BP vehicle, for up to 43 consecutive days (including a 2-week maturation phase, pairing, gestation and early lactation for females). There were no treatment-related developmental effects in the litter parameters evaluated or on any reproductive effects. Thus, the NOAEL for developmental and reproductive toxicity was considered to be 1000 mg/kg/day, the highest dose tested (RIFM, 2010). Therefore, the butanoic acid, 3a,4,5,6,7,7a-hexahydro-4,7-methano-1H-indenyl ester MOE for the developmental and reproductive toxicity endpoints can be calculated by dividing the acetoxydihydrodicyclopentadiene NOAEL in mg/kg/day by the total systemic exposure to butanoic acid, 3a,4,5,6,7,7a-hexahydro-4,7-methano-1H-indenyl ester, 1000/0.012 or 83,333.",

year = "2018",

month = sep,

doi = "10.1016/j.fct.2018.06.041",

language = "English (US)",

volume = "118",

pages = "S84--S93",

journal = "Food and Chemical Toxicology",

issn = "0278-6915",

publisher = "Elsevier Limited",

}

TY - JOUR

T1 - RIFM FRAGRANCE INGREDIENT SAFETY ASSESSMENT, butanoic acid, 3a,4,5,6,7,7a-hexahydro-4,7-methano-1H-indenyl ester, CAS Registry Number 113889-23-9

AU - Api, A. M.

AU - Belsito, D.

AU - Botelho, D.

AU - Bruze, M.

AU - Burton, G. A.

AU - Buschmann, J.

AU - Dagli, M. L.

AU - Date, M.

AU - Dekant, W.

AU - Deodhar, C.

AU - Francis, M.

AU - Fryer, A. D.

AU - Jones, L.

AU - Joshi, K.

AU - La Cava, S.

AU - Lapczynski, A.

AU - Liebler, D. C.

AU - O'Brien, D.

AU - Patel, A.

AU - Penning, T. M.

AU - Ritacco, G.

AU - Romine, J.

AU - Sadekar, N.

AU - Salvito, D.

AU - Schultz, T. W.

AU - Sipes, I. G.

AU - Sullivan, G.

AU - Thakkar, Y.

AU - Tokura, Y.

AU - Tsang, S.

N1 - Funding Information: There are no developmental or reproductive toxicity data on butanoic acid, 3a,4,5,6,7,7a-hexahydro-4,7-methano-1H-indenyl ester. Read-across material acetoxydihydrodicyclopentadiene (CAS # 54830-99-8; see Section V) has sufficient developmental and reproductive toxicity data to support the developmental and reproductive toxicity endpoints. An OECD 421 oral gavage reproduction and developmental toxicity screening test was conducted in Wistar Han:HsdRccHan:WIST strain rats. Groups of 10 rats/sex/dose were administered via oral gavage with test material acetoxydihydrodicyclopentadiene (mixture of isomers) at doses of 0, 100, 300, or 1000 mg/kg/day in an Arachis oil BP vehicle, for up to 43 consecutive days (including a 2-week maturation phase, pairing, gestation and early lactation for females). There were no treatment-related developmental effects in the litter parameters evaluated or on any reproductive effects. Thus, the NOAEL for developmental and reproductive toxicity was considered to be 1000 mg/kg/day, the highest dose tested (RIFM, 2010). Therefore, the butanoic acid, 3a,4,5,6,7,7a-hexahydro-4,7-methano-1H-indenyl ester MOE for the developmental and reproductive toxicity endpoints can be calculated by dividing the acetoxydihydrodicyclopentadiene NOAEL in mg/kg/day by the total systemic exposure to butanoic acid, 3a,4,5,6,7,7a-hexahydro-4,7-methano-1H-indenyl ester, 1000/0.012 or 83,333.

PY - 2018/9

Y1 - 2018/9

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UR - http://www.scopus.com/inward/citedby.url?scp=85049472426&partnerID=8YFLogxK

U2 - 10.1016/j.fct.2018.06.041

DO - 10.1016/j.fct.2018.06.041

M3 - Short survey

C2 - 29936278

AN - SCOPUS:85049472426

SN - 0278-6915

VL - 118

SP - S84-S93

JO - Food and Chemical Toxicology

JF - Food and Chemical Toxicology

ER -

RIFM FRAGRANCE INGREDIENT SAFETY ASSESSMENT, butanoic acid, 3a,4,5,6,7,7a-hexahydro-4,7-methano-1H-indenyl ester, CAS Registry Number 113889-23-9

ASJC Scopus subject areas

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