TY - JOUR
T1 - Risk of Suicide-Related Outcomes After SARS-COV-2 Infection
T2 - Results from a Nationwide Observational Matched Cohort of US Veterans
AU - Hynes, Denise M.
AU - Niederhausen, Meike
AU - Chen, Jason I.
AU - Shahoumian, Troy A.
AU - Rowneki, Mazhgan
AU - Hickok, Alex
AU - Shepherd-Banigan, Megan
AU - Hawkins, Eric J.
AU - Naylor, Jennifer
AU - Teo, Alan
AU - Govier, Diana J.
AU - Berry, Kristin
AU - McCready, Holly
AU - Osborne, Thomas F.
AU - Wong, Edwin
AU - Hebert, Paul L.
AU - Smith, Valerie A.
AU - Bowling, C. Barrett
AU - Boyko, Edward J.
AU - Ioannou, George N.
AU - Iwashyna, Theodore J.
AU - Maciejewski, Matthew L.
AU - O’Hare, Ann M.
AU - Viglianti, Elizabeth M.
AU - Bohnert, Amy S.B.
N1 - Publisher Copyright:
© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023.
PY - 2024/3
Y1 - 2024/3
N2 - Background: Negative mental health-related effects of SARS-COV-2 infection are increasingly evident. However, the impact on suicide-related outcomes is poorly understood, especially among populations at elevated risk. Objective: To determine risk of suicide attempts and other self-directed violence (SDV) after SARS-COV-2 infection in a high-risk population. Design: We employed an observational design supported by comprehensive electronic health records from the Veterans Health Administration (VHA) to examine the association of SARS-COV-2 infection with suicide attempts and other SDV within one year of infection. Veterans with SARS-COV-2 infections were matched 1:5 with non-infected comparators each month. Three periods after index were evaluated: days 1–30, days 31–365, and days 1–365. Participants: VHA patients infected with SARS-COV-2 between March 1, 2020 and March 31, 2021 and matched non-infected Veteran comparators. Main Measures: Suicide attempt and other SDV events for the COVID-19 and non-infected comparator groups were analyzed using incidence rates per 100,000 person years and hazard ratios from Cox regressions modeling time from matched index date to first event. Subgroups were also examined. Key Results: 198,938 veterans with SARS-COV-2 (COVID-19 group) and 992,036 comparators were included. Unadjusted one-year incidence per 100,000 for suicide attempt and other SDV was higher among the COVID-19 group: 355 vs 250 and 327 vs 235, respectively. The COVID-19 group had higher risk than comparators for suicide attempts: days 1–30 hazard ratio (HR) = 2.54 (CI:2.05, 3.15), days 31–365 HR = 1.30 (CI:1.19, 1.43) and days 1–365 HR = 1.41 (CI:1.30, 1.54), and for other SDV: days 1–30 HR = 1.94 (CI:1.51, 2.49), days 31–365 HR = 1.32 (CI:1.20, 1.45) and days 1–365 HR = 1.38 (CI:1.26, 1.51). Conclusions: COVID-19 patients had higher risks of both suicide attempts and other forms of SDV compared to uninfected comparators, which persisted for at least one year after infection. Results support suicide risk screening of those infected with SARS-COV-2 to identify opportunities to prevent self-harm.
AB - Background: Negative mental health-related effects of SARS-COV-2 infection are increasingly evident. However, the impact on suicide-related outcomes is poorly understood, especially among populations at elevated risk. Objective: To determine risk of suicide attempts and other self-directed violence (SDV) after SARS-COV-2 infection in a high-risk population. Design: We employed an observational design supported by comprehensive electronic health records from the Veterans Health Administration (VHA) to examine the association of SARS-COV-2 infection with suicide attempts and other SDV within one year of infection. Veterans with SARS-COV-2 infections were matched 1:5 with non-infected comparators each month. Three periods after index were evaluated: days 1–30, days 31–365, and days 1–365. Participants: VHA patients infected with SARS-COV-2 between March 1, 2020 and March 31, 2021 and matched non-infected Veteran comparators. Main Measures: Suicide attempt and other SDV events for the COVID-19 and non-infected comparator groups were analyzed using incidence rates per 100,000 person years and hazard ratios from Cox regressions modeling time from matched index date to first event. Subgroups were also examined. Key Results: 198,938 veterans with SARS-COV-2 (COVID-19 group) and 992,036 comparators were included. Unadjusted one-year incidence per 100,000 for suicide attempt and other SDV was higher among the COVID-19 group: 355 vs 250 and 327 vs 235, respectively. The COVID-19 group had higher risk than comparators for suicide attempts: days 1–30 hazard ratio (HR) = 2.54 (CI:2.05, 3.15), days 31–365 HR = 1.30 (CI:1.19, 1.43) and days 1–365 HR = 1.41 (CI:1.30, 1.54), and for other SDV: days 1–30 HR = 1.94 (CI:1.51, 2.49), days 31–365 HR = 1.32 (CI:1.20, 1.45) and days 1–365 HR = 1.38 (CI:1.26, 1.51). Conclusions: COVID-19 patients had higher risks of both suicide attempts and other forms of SDV compared to uninfected comparators, which persisted for at least one year after infection. Results support suicide risk screening of those infected with SARS-COV-2 to identify opportunities to prevent self-harm.
KW - COVID-19
KW - mental health
KW - self-directed violence
KW - suicide attempt
KW - veterans
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U2 - 10.1007/s11606-023-08440-9
DO - 10.1007/s11606-023-08440-9
M3 - Article
C2 - 37884839
AN - SCOPUS:85174852741
SN - 0884-8734
VL - 39
SP - 626
EP - 635
JO - Journal of general internal medicine
JF - Journal of general internal medicine
IS - 4
ER -